{"id":"W1591925493","doi":"10.1179/1476830515y.0000000034","title":"Western diet-induced anxiolytic effects in mice are associated with alterations in tryptophan metabolism","year":2015,"lang":"en","type":"article","venue":"Nutritional Neuroscience","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Endocrinology; Internal medicine; Tryptophan hydroxylase; Elevated plus maze; Tryptophan; Serotonin; Anxiolytic; Brain-derived neurotrophic factor; Chemistry; Neurotrophic factors; Biology; Serotonergic; Medicine; Biochemistry; Amino acid; Anxiety; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002518528,0.0002218233,0.0002584813,0.0003440659,0.0001241952,0.000117491,0.0004028713,0.00007730772,0.00000394889],"category_scores_gemma":[0.001978246,0.0002050406,0.00004161171,0.001805572,0.0002132311,0.000748043,0.00006639177,0.0003132578,0.00002244362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032061,"about_ca_system_score_gemma":0.0001325264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002462828,"about_ca_topic_score_gemma":0.0002525743,"domain_scores_codex":[0.9974688,0.0003424066,0.000277111,0.0006439881,0.0006991064,0.0005685977],"domain_scores_gemma":[0.9989549,0.0004544943,0.0001247496,0.0001798919,0.00005332673,0.0002326176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003895666,0.002943528,0.03757219,0.00004421831,0.000001614841,0.0003774256,0.0006668096,0.001058046,0.9525907,0.004048979,0.0001797745,0.0001271563],"study_design_scores_gemma":[0.005017356,0.0003697402,0.8907447,0.0002315458,0.000005493826,0.00004753886,0.0001072338,0.002639412,0.0981544,0.001974282,0.0002462009,0.0004620877],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975276,0.00007897326,0.00007507221,0.001034306,0.0003828128,0.0004720705,0.00003072645,0.00007456762,0.0003238653],"genre_scores_gemma":[0.996404,0.000009957456,0.00006011021,0.00325667,0.00005578438,0.0001116654,0.000005579684,0.00001990211,0.00007636246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8544363,"threshold_uncertainty_score":0.8361313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04639954600320893,"score_gpt":0.274710451397617,"score_spread":0.228310905394408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}