{"id":"W1592012543","doi":"10.1002/cbic.201500272","title":"BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses","year":2015,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Academy of Finland; Ontario Ministry of Economic Development and Innovation; Janssen Biotech; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; AbbVie; Novartis Foundation; GlaxoSmithKline; Pfizer","keywords":"Bromodomain; Epigenetics; Sirtuin 1; Acetylation; Histone; Sirtuin; Chromatin; BET inhibitor; Cell biology; BRD4; Biology; Chemistry; Downregulation and upregulation; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110773,0.000457629,0.000560989,0.0003912605,0.0001839173,0.0002418156,0.0002005996,0.0002840139,0.002388697],"category_scores_gemma":[0.0001054513,0.0001582249,0.0002906096,0.0002151163,0.0002409861,0.0002320596,0.0001677413,0.0009780993,0.0004987529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160388,"about_ca_system_score_gemma":0.0002407537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003608082,"about_ca_topic_score_gemma":0.0007133207,"domain_scores_codex":[0.9998965,0.00001169735,0.000008693387,0.00001464608,0.00003219304,0.00003626811],"domain_scores_gemma":[0.9999441,0.000006423472,0.0000144145,0.000004900188,0.000007518341,0.00002260799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001211145,0.0002518687,0.000199526,0.0001183432,0.00002541545,0.00006609686,0.00001605147,0.0001132754,0.9922192,0.0002004727,0.0003371972,0.005241497],"study_design_scores_gemma":[0.0002785307,0.002061123,0.007114733,0.00001798167,0.00008515765,0.0002792094,0.00004021346,0.001390026,0.9788938,0.0002126686,0.009613014,0.00001344366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835053,0.007916177,0.003244001,0.0004794158,0.0002836835,0.00005081859,0.0006644079,0.0003679602,0.003488157],"genre_scores_gemma":[0.9870178,0.003839985,0.001836048,0.0002661011,0.00006685703,0.00005802466,0.001172148,0.00004181464,0.005701301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002388697,"threshold_uncertainty_score":0.007990956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688444341913204,"score_gpt":0.2387085414018973,"score_spread":0.2218240979827653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}