{"id":"W1592308846","doi":"10.1038/ni.3194","title":"The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance","year":2015,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Exercise and Physiological Responses","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Novo Nordisk Fonden; National Metal and Materials Technology Center","keywords":"Autoimmune regulator; Regulator; Sirtuin; Sirtuin 1; Biology; Transcriptional regulation; Cell biology; Central tolerance; Autoimmunity; Regulation of gene expression; HDAC4; Immune tolerance; Gene; Gene expression; Transcription factor; Immunology; Genetics; Antigen; Downregulation and upregulation; Acetylation; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004248474,0.0004382996,0.000563453,0.0002701923,0.0003023118,0.0005322613,0.0003878076,0.0003192517,0.002553717],"category_scores_gemma":[0.0003406404,0.0002450821,0.0004903867,0.000139143,0.000474113,0.0003336151,0.0006866404,0.0009680765,0.0006650904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267192,"about_ca_system_score_gemma":0.0002223303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000205866,"about_ca_topic_score_gemma":0.0005004558,"domain_scores_codex":[0.9997051,0.00004952996,0.00001660018,0.00007702567,0.00007444851,0.00007719915],"domain_scores_gemma":[0.9997179,0.00002702979,0.00007319854,0.00003838775,0.00005577916,0.0000877234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009687825,0.00005933726,0.00178786,0.0001561788,0.00006471544,0.0001214079,0.00003720157,0.0001117386,0.9853221,0.0006721984,0.0005679033,0.01013043],"study_design_scores_gemma":[0.0001956898,0.001026314,0.09144031,0.00006310642,0.0001495902,0.0007388277,0.0002212403,0.001500505,0.8832738,0.001423805,0.01993429,0.0000323979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505455,0.02386833,0.01422563,0.001412245,0.001054132,0.00005682887,0.0008218753,0.0004880722,0.007527357],"genre_scores_gemma":[0.991388,0.002447519,0.001696467,0.0001810509,0.000131799,0.00002004339,0.0005281948,0.00004963124,0.003557346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553717,"threshold_uncertainty_score":0.008543074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705295977247649,"score_gpt":0.2977666841694169,"score_spread":0.2807137243969404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}