{"id":"W1592578892","doi":"10.1080/19420862.2015.1029215","title":"Production of α2,6-sialylated IgG1 in CHO cells","year":2015,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Manitoba; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Glycan; Sialic acid; Sialyltransferase; Chemistry; Antibody; SIGLEC; Galactosyltransferase; Mutant; Biochemistry; Glycosylation; N-Acetylneuraminic acid; Fragment crystallizable region; Molecular biology; Biology; Glycoprotein; Gene; Enzyme; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007164163,0.001110249,0.0008066953,0.0004911321,0.0003243765,0.0006916018,0.001036852,0.0006814045,0.001217627],"category_scores_gemma":[0.0003523588,0.000434662,0.0008678135,0.0009305032,0.0003534093,0.0003765964,0.0007760866,0.001449784,0.002307975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009783146,"about_ca_system_score_gemma":0.0004757892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003419277,"about_ca_topic_score_gemma":0.002153674,"domain_scores_codex":[0.9993735,0.0001001329,0.00008321093,0.0001195696,0.0001948747,0.0001287534],"domain_scores_gemma":[0.9997714,0.00003062834,0.00004078732,0.00008076127,0.00004442614,0.00003201928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006798708,0.00001940592,0.00007186704,0.0000614129,0.000007850983,0.00004426676,0.00003629375,0.00006662544,0.9986845,0.00009819735,0.0000564726,0.0007851893],"study_design_scores_gemma":[0.00002935824,0.0001745311,0.0009191928,0.00001192753,0.00002418391,0.000153374,0.00002815707,0.0006899497,0.9915981,0.00004834405,0.006312165,0.00001068293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.931644,0.005399202,0.04334624,0.0006513316,0.0005617347,0.0006622795,0.008229224,0.0008888972,0.008617201],"genre_scores_gemma":[0.8810579,0.005291284,0.06557581,0.0002544378,0.0001392568,0.0007339813,0.02383783,0.0003692175,0.02274032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003419277,"threshold_uncertainty_score":0.007098258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05900827417885001,"score_gpt":0.3330740630077162,"score_spread":0.2740657888288662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}