{"id":"W1592578892","doi":"10.1080/19420862.2015.1029215","title":"Production of α2,6-sialylated IgG1 in CHO cells","year":2015,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Manitoba; National Research Council Canada","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chinese hamster ovary cell; Glycan; Sialic acid; Sialyltransferase; Chemistry; Antibody; SIGLEC; Galactosyltransferase; Mutant; Biochemistry; Glycosylation; N-Acetylneuraminic acid; Fragment crystallizable region; Molecular biology; Biology; Glycoprotein; Gene; Enzyme; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002505822,0.00005749254,0.0001552023,0.0001080088,0.00001043909,0.000002903549,0.00004567677,0.00004296583,0.0001198177],"category_scores_gemma":[0.00008730985,0.00004395038,0.00003176797,0.0002247902,0.0000516317,0.00003212165,0.00003012446,0.0001248422,0.0001257573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003359622,"about_ca_system_score_gemma":0.00008044358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004579097,"about_ca_topic_score_gemma":0.00003573375,"domain_scores_codex":[0.9992747,0.00002802944,0.0001613184,0.0001272275,0.0002606525,0.0001481088],"domain_scores_gemma":[0.9996068,0.00001312908,0.00002820375,0.0001323048,0.0001222394,0.00009726683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003962486,0.001093186,0.1571851,0.0006559648,0.0001001049,0.0002027304,0.002505838,0.0001624532,0.7183312,0.0009581484,0.06425251,0.05059034],"study_design_scores_gemma":[0.003123995,0.0008359647,0.1688719,0.0002637201,0.00003259076,0.00008732986,0.0003906852,0.0007056063,0.6037443,0.0008943942,0.2208215,0.000228069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875112,0.0002291368,0.000002920506,0.002887065,0.0002422202,0.0002536505,0.000002426357,0.00001356295,0.008857826],"genre_scores_gemma":[0.9836419,0.00005324885,0.0001833544,0.00006419719,0.0001716792,0.000007664379,0.00001592753,0.000006990244,0.01585501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.156569,"threshold_uncertainty_score":0.1792245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05900827417885001,"score_gpt":0.3330740630077162,"score_spread":0.2740657888288662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}