{"id":"W1593851516","doi":"","title":"Abstract 11847: Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis","year":2014,"lang":"en","type":"review","venue":"Circulation","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Dosing; Medicine; Vitamin K antagonist; VKORC1; Meta-analysis; Genotype; Internal medicine; Algorithm; Randomized controlled trial; Warfarin; Gastroenterology; CYP2C9; Atrial fibrillation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01271515,0.002515836,0.0171004,0.006651161,0.0005234722,0.00374436,0.001999348,0.002273308,0.006362729],"category_scores_gemma":[0.03287764,0.001180132,0.02815904,0.007473667,0.0007520521,0.001991803,0.001218525,0.001922227,0.0004844993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002625239,"about_ca_system_score_gemma":0.003649005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006818027,"about_ca_topic_score_gemma":0.01147908,"domain_scores_codex":[0.9908503,0.004653915,0.002365796,0.0008040246,0.001062885,0.0002631858],"domain_scores_gemma":[0.9801785,0.01482328,0.003253181,0.0004002172,0.001135989,0.0002087483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001568307,0.00002817912,0.002330563,0.5305191,0.4495251,0.000105088,0.00007091253,0.0005376582,0.0002028337,0.0001328533,0.001258707,0.01372064],"study_design_scores_gemma":[0.001025499,0.0001825843,0.00345826,0.05326088,0.9393698,0.00008440008,0.00003792596,0.0002730026,0.0001281686,0.0002470763,0.001906362,0.00002602641],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003393872,0.9941015,0.0005640478,0.0003682661,0.0001799405,0.0003996345,0.0006334546,0.00003758537,0.000321686],"genre_scores_gemma":[0.1511869,0.8407561,0.002933793,0.001417424,0.0004204615,0.001693489,0.001005088,0.00004939052,0.000537363],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0171004,"threshold_uncertainty_score":0.06724495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1889203552280274,"score_gpt":0.4617229990521668,"score_spread":0.2728026438241393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}