{"id":"W159390156","doi":"10.4049/jimmunol.184.supp.36.22","title":"SHP2 protein-tyrosine phosphatase is a key regulator of mast cell signaling and development in mice (36.22)","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Cell biology; Mast cell; Protein tyrosine phosphatase; Proto-oncogene tyrosine-protein kinase Src; Biology; Cre recombinase; Knockout mouse; Receptor tyrosine kinase; Kinase; Signal transduction; Conditional gene knockout; Phosphorylation; Genetically modified mouse; Receptor; Immunology; Transgene; Phenotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004254488,0.00122053,0.0003737709,0.001274192,0.0005329791,0.0005604791,0.000584292,0.001104096,0.009043164],"category_scores_gemma":[0.0001655688,0.0005651462,0.0006892282,0.0004587776,0.0005497676,0.0005049268,0.0006183514,0.001641049,0.003102445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005521041,"about_ca_system_score_gemma":0.0003819946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008288331,"about_ca_topic_score_gemma":0.001503442,"domain_scores_codex":[0.9994001,0.00007623479,0.00006041456,0.0001546499,0.0001859824,0.0001226483],"domain_scores_gemma":[0.9997285,0.00002100086,0.00008444706,0.0000292822,0.00002387085,0.0001128387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000173502,0.00004342132,0.0002695956,0.00005544093,0.000007963498,0.0001661749,0.00002065921,0.00004444128,0.9964876,0.0004162589,0.0003637398,0.001951177],"study_design_scores_gemma":[0.0001152853,0.0003271733,0.008252664,0.00003694166,0.00004371871,0.001426693,0.00006040442,0.001113676,0.9613061,0.0002273766,0.02707772,0.00001225574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8937243,0.007176976,0.05679546,0.001787387,0.0006961171,0.0006133146,0.01737598,0.003434356,0.01839608],"genre_scores_gemma":[0.8991099,0.004122909,0.02698089,0.0005061987,0.000114768,0.001346077,0.01053017,0.0007008233,0.0565882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009043164,"threshold_uncertainty_score":0.0302524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00613553778495258,"score_gpt":0.2120693906078651,"score_spread":0.2059338528229126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}