{"id":"W1594081613","doi":"10.1002/9780470686263.ch4","title":"Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures","year":2010,"lang":"en","type":"other","venue":"","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Physiologically based pharmacokinetic modelling; Pharmacokinetics; Chemistry; Computer science; Computational biology; Biochemical engineering; Data science; Pharmacology; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003482701,0.0008039702,0.0009402474,0.0004301323,0.0004199478,0.001357712,0.001321539,0.001306754,0.006496558],"category_scores_gemma":[0.0008802392,0.0006180104,0.0009187992,0.000559224,0.0004311183,0.001281312,0.0006727768,0.001194513,0.002502861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008767333,"about_ca_system_score_gemma":0.001196446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005810498,"about_ca_topic_score_gemma":0.003139297,"domain_scores_codex":[0.9996928,0.00006972991,0.00001502165,0.00004243013,0.0001618649,0.00001823714],"domain_scores_gemma":[0.9997957,0.0001112269,0.00002671906,0.00001265539,0.00004383958,0.000009812805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003094526,0.00004325084,0.0002112124,0.0001140304,0.0000281892,0.00007571224,0.00003463174,0.9290271,0.005568933,0.04355132,0.002813369,0.0185014],"study_design_scores_gemma":[0.00000815356,0.00001196914,0.000118246,0.00001140909,0.000009623711,0.00004085639,0.000004103262,0.982634,0.001306402,0.009182252,0.006662636,0.00001027703],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01240126,0.004325848,0.926157,0.0009316007,0.0002988114,0.0001666257,0.0009421652,0.00094399,0.05383262],"genre_scores_gemma":[0.4348601,0.0180244,0.3442805,0.001176356,0.0007889046,0.001283141,0.002096791,0.00100149,0.1964884],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006496558,"threshold_uncertainty_score":0.02173311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1139473414296995,"score_gpt":0.4488184450313272,"score_spread":0.3348711036016276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}