{"id":"W1594559377","doi":"10.18433/j3630v","title":"Nanoparticle-Mediated Interleukin-12 Cancer Gene Therapy","year":2010,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Gene delivery; Genetic enhancement; Immune system; Transfection; Systemic administration; DNA vaccination; In vivo; Naked DNA; Gene; Viral vector; Cancer research; Biology; Cytokine; Immunology; Genetics; Immunization","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002321798,0.0004955239,0.0009867052,0.0002157664,0.0002166425,0.0001527821,0.001810846,0.0002279215,0.0009532331],"category_scores_gemma":[0.000155507,0.0003284667,0.0007326344,0.000561209,0.000852104,0.00002943708,0.0002271447,0.001299405,0.00005093333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007723091,"about_ca_system_score_gemma":0.00198603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009605968,"about_ca_topic_score_gemma":0.00002111423,"domain_scores_codex":[0.9960238,0.0006050192,0.001067093,0.0005418838,0.0009653272,0.0007968171],"domain_scores_gemma":[0.9979473,0.0001580526,0.0006904781,0.0002755357,0.0002839509,0.0006446354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005401586,0.0001609229,0.00006118023,0.0001865171,0.0002188098,0.00003114004,0.00001432215,0.000004475432,0.2808114,0.000001276043,0.0007754592,0.7171944],"study_design_scores_gemma":[0.00111104,0.001001799,0.000001101898,0.0002789411,0.0001723509,0.0001844486,0.000004518663,0.00004753411,0.2141511,0.00000493072,0.7827444,0.0002977677],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05833283,0.9395399,0.000008155418,0.0003818016,0.001142767,0.0004219178,0.00004743953,0.00001011467,0.0001150775],"genre_scores_gemma":[0.004749143,0.992206,0.0001157807,0.0007620503,0.00193378,0.00004191191,0.00001233238,0.00005562352,0.0001234169],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.781969,"threshold_uncertainty_score":0.99996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1695237023307867,"score_gpt":0.5014346873707306,"score_spread":0.3319109850399439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}