{"id":"W1595298938","doi":"10.1111/cei.12465","title":"Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice","year":2014,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institutes of Health Research; University of Massachusetts Medical School; National Cancer Institute; National Institutes of Health; National Institute on Drug Abuse; Canadian Diabetes Association","keywords":"Cytotoxic T cell; Biology; Antigen; Immunology; T cell; CD8; Major histocompatibility complex; Antigen-presenting cell; T-cell receptor; Cell biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006752477,0.0005641916,0.0004365655,0.0004677657,0.0002263377,0.0007503479,0.0006967155,0.0006711957,0.001605871],"category_scores_gemma":[0.0003089245,0.0004825626,0.0004597488,0.0002890305,0.000390797,0.0003396837,0.000382291,0.001673763,0.0009454439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004116,"about_ca_system_score_gemma":0.0003202045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005812055,"about_ca_topic_score_gemma":0.0004556398,"domain_scores_codex":[0.9993087,0.0001147104,0.000129205,0.0001411187,0.0001751544,0.0001311079],"domain_scores_gemma":[0.9997552,0.00004195033,0.00007128483,0.00005691816,0.00002801614,0.0000465928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000225262,0.0001535294,0.0001714206,0.00007112024,0.00001392088,0.000118064,0.0001074616,0.0003058236,0.9922251,0.0007450215,0.000266726,0.005596611],"study_design_scores_gemma":[0.0002037473,0.0008105424,0.001378609,0.00002651856,0.00004913772,0.0008262889,0.00003450607,0.003329611,0.9768579,0.0001532402,0.01631255,0.00001734544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8850566,0.004616731,0.09547076,0.0006346536,0.0003934216,0.002066683,0.003279877,0.00187812,0.006603169],"genre_scores_gemma":[0.9487272,0.002327529,0.03499566,0.0002156149,0.00005915833,0.001334982,0.003111881,0.0001973611,0.009030677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605871,"threshold_uncertainty_score":0.005372167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09438824903010129,"score_gpt":0.3820104620963217,"score_spread":0.2876222130662204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}