{"id":"W1595298938","doi":"10.1111/cei.12465","title":"Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice","year":2014,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institutes of Health Research; University of Massachusetts Medical School; National Cancer Institute; National Institutes of Health; National Institute on Drug Abuse; Canadian Diabetes Association","keywords":"Cytotoxic T cell; Biology; Antigen; Immunology; T cell; CD8; Major histocompatibility complex; Antigen-presenting cell; T-cell receptor; Cell biology; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001075094,0.0003008977,0.0008153729,0.0001928145,0.000162287,0.0000252639,0.0002196236,0.0003545089,0.0008215406],"category_scores_gemma":[0.000009630246,0.0002807179,0.000278404,0.0001900751,0.0009360139,0.0001018298,0.00007926289,0.0006343814,0.00002164993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001376941,"about_ca_system_score_gemma":0.00003636448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001593691,"about_ca_topic_score_gemma":0.00002010989,"domain_scores_codex":[0.9967239,0.0007571827,0.001142774,0.0006749679,0.0002308617,0.000470288],"domain_scores_gemma":[0.99899,0.0001543961,0.000181775,0.0005208767,0.00006394211,0.00008900807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000621148,0.001924169,0.001390456,0.00001969471,0.0000854516,0.000002111423,0.001011351,0.000001834224,0.9928756,0.0001307038,0.0001297078,0.001807734],"study_design_scores_gemma":[0.005865261,0.003003212,0.007886242,0.00003147596,0.00001396298,0.000009622953,0.0008971994,0.00006708717,0.9792442,0.0000162023,0.002741235,0.0002242851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903705,0.00723701,0.0001807564,0.00006865959,0.0007374363,0.0006635224,0.00001255365,0.00003667325,0.0006928734],"genre_scores_gemma":[0.9973124,0.001543205,0.00006677327,0.0000517377,0.0002123998,0.00003768861,0.0001518451,0.00005268368,0.0005712624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01363142,"threshold_uncertainty_score":0.9999645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09438824903010129,"score_gpt":0.3820104620963217,"score_spread":0.2876222130662204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}