{"id":"W1595433728","doi":"","title":"Abstract 11698: Pulmonary Hypertension in S100A1 KO Mice is Associated With Endothelial Cell Dysfunction and Impaired eNOS Activation Dependent in Part on the Receptor for Advanced Glycation End-Products (RAGE)","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Enos; Medicine; Pulmonary hypertension; Internal medicine; Endothelial dysfunction; Endocrinology; Rage (emotion); Nitric oxide; Endothelium; In vivo; Glycation; Basal (medicine); Endothelial stem cell; Receptor; Nitric oxide synthase; Diabetes mellitus; In vitro; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931966,0.001009893,0.0005041872,0.0007622699,0.0002645025,0.0004485259,0.0003526004,0.0009060256,0.007875015],"category_scores_gemma":[0.0001386917,0.0004143791,0.0004085287,0.0002093095,0.0008087241,0.0003457466,0.0003041736,0.001990926,0.001201176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986014,"about_ca_system_score_gemma":0.0001756687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003666678,"about_ca_topic_score_gemma":0.0004542261,"domain_scores_codex":[0.9997411,0.00003331817,0.00003557093,0.00006824588,0.00007964559,0.00004215464],"domain_scores_gemma":[0.9996451,0.00003197374,0.0001404559,0.00001924881,0.00001808504,0.0001450325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003924317,0.0001061035,0.0002397242,0.00004902938,0.00001013783,0.0001684341,0.00001853805,0.00002615084,0.9979861,0.0001108747,0.0001052899,0.0007871045],"study_design_scores_gemma":[0.000222717,0.001280257,0.02243636,0.00005998423,0.00007955407,0.002786929,0.0001132999,0.001381965,0.9671991,0.0002629942,0.004158415,0.00001827811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916329,0.0005835858,0.004028891,0.0005358153,0.000127271,0.0000450646,0.001664196,0.0002217642,0.001160386],"genre_scores_gemma":[0.9777182,0.0008977287,0.004719622,0.0002500679,0.00007087217,0.0001571064,0.002116302,0.0001700469,0.01389998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007875015,"threshold_uncertainty_score":0.0263446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354194114641546,"score_gpt":0.2043686302726503,"score_spread":0.1908266891262348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}