{"id":"W1595511160","doi":"10.1139/o07-013","title":"Anti-CD3 scFv-B7.1 fusion protein expressed on the surface of HeLa cells provokes potent T-lymphocyte activation and cytotoxicityThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process.","year":2007,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Shanxi Province; National Natural Science Foundation of China; University of Cambridge","keywords":"Cytotoxic T cell; Molecular biology; Fusion protein; CD3; Biology; T cell; CD28; HeLa; CD8; Cell biology; Transfection; Cell culture; Cell; Recombinant DNA; In vitro; Antigen; Gene; Immune system; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101912,0.0004436693,0.0003344635,0.0002241679,0.0001747007,0.0003096761,0.000160361,0.0003601192,0.001359821],"category_scores_gemma":[0.00007154328,0.0001178554,0.0002959856,0.0002019863,0.0001655708,0.0001811236,0.0002072812,0.0005972133,0.0007385232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003645301,"about_ca_system_score_gemma":0.0002071044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004967682,"about_ca_topic_score_gemma":0.0005903696,"domain_scores_codex":[0.9998311,0.00002034808,0.000009370509,0.00004222498,0.00005089707,0.000046067],"domain_scores_gemma":[0.999948,0.00001223857,0.00001051389,0.000008170568,0.000008476057,0.00001266864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001368617,0.000005697147,0.00002940225,0.00001403901,0.000001922042,0.00002109234,0.000005674773,0.00001061614,0.9995436,0.00002739339,0.0000257929,0.0003009699],"study_design_scores_gemma":[0.000005211049,0.00008702892,0.001056006,0.000004930425,0.00001182366,0.0001724751,0.00001695979,0.0005315709,0.9956454,0.00002173566,0.002444177,0.000002593478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767656,0.004638903,0.01181327,0.0001729351,0.0001551248,0.00008237686,0.000801218,0.0001932194,0.005377256],"genre_scores_gemma":[0.9820305,0.002269749,0.007767792,0.0001053723,0.00003578138,0.00005485697,0.001880208,0.00004185547,0.005813944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359821,"threshold_uncertainty_score":0.004549026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963877229774045,"score_gpt":0.3326772668754189,"score_spread":0.3030384945776785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}