{"id":"W1596851294","doi":"10.1161/circ.129.suppl_1.48","title":"Abstract 48: A newly identified rare variant (chr11:47227430) with possible functional activity is associated with fasting insulin at the chromosome 11p11.2-NR1H3 locus in the Cohorts for Heart and Aging Research in Genetic Epidemiology Targeted Sequencing Study (CHARGE-TSS).","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Locus (genetics); Genetics; Biology; Allele; Minor allele frequency; Genetic association; Genome-wide association study; Gene; Single-nucleotide polymorphism; Allele frequency; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003945965,0.0006783133,0.0005472878,0.0007106724,0.0007562018,0.0005409304,0.0005427747,0.0007880657,0.01388258],"category_scores_gemma":[0.001463709,0.0001850457,0.0007085037,0.001031051,0.0004478769,0.0002037457,0.000526451,0.000810212,0.001015667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002106216,"about_ca_system_score_gemma":0.0002497537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002927165,"about_ca_topic_score_gemma":0.004329845,"domain_scores_codex":[0.9994578,0.00007447482,0.0000538002,0.0002637971,0.00008271268,0.00006742371],"domain_scores_gemma":[0.9993793,0.0002359072,0.0001508951,0.00007655698,0.00003580933,0.0001214578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007700604,0.0003060485,0.7508524,0.0006486222,0.001357829,0.01894103,0.000823675,0.001084544,0.1591498,0.00120027,0.009785165,0.04814997],"study_design_scores_gemma":[0.0004230526,0.0005494489,0.9625301,0.00008838637,0.0007054929,0.01470088,0.0001773344,0.001934651,0.008714724,0.0008629943,0.009256416,0.00005647025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854262,0.0006556929,0.00406535,0.0003421543,0.0001376716,0.00005153421,0.0077753,0.0001480409,0.001398029],"genre_scores_gemma":[0.9921592,0.0001100816,0.001732429,0.0002688501,0.00009247481,0.00005995317,0.003897559,0.00006425292,0.001615199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01388258,"threshold_uncertainty_score":0.04644185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06773836822064716,"score_gpt":0.3209787529246749,"score_spread":0.2532403847040277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}