{"id":"W1596914918","doi":"10.18433/j3dw3s","title":"Pharmacokinetics of a Cytochrome P450 2E1 Probe, Chlorzoxazone, and its 6-Hydroxy Metabolite in Poloxamer 407-Induced Hyperlipidemic Rats","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation of Korea; Catholic University of Korea; National Research Foundation","keywords":"Chlorzoxazone; CYP2E1; Pharmacokinetics; Chemistry; Metabolite; Pharmacology; Cytochrome P450; In vivo; Active metabolite; Metabolism; Biochemistry; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991337,0.0004378884,0.0004758815,0.0004166527,0.0001524796,0.0002685845,0.0001285748,0.0003876621,0.0007646297],"category_scores_gemma":[0.0002150181,0.0002189282,0.0002847863,0.0002415986,0.0003804816,0.0003761606,0.0001019284,0.0009040108,0.0001800117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004224692,"about_ca_system_score_gemma":0.0003099999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142395,"about_ca_topic_score_gemma":0.001214235,"domain_scores_codex":[0.9998368,0.00003111498,0.00001099883,0.00004257105,0.00004747442,0.00003105803],"domain_scores_gemma":[0.9997304,0.00003002313,0.000115758,0.00002922172,0.00002912751,0.00006548861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005543426,0.0003665731,0.001598918,0.00003779237,0.00002800985,0.00005371609,0.00004422828,0.0002010635,0.9877595,0.00004190985,0.00006887863,0.004255949],"study_design_scores_gemma":[0.0002790165,0.01416687,0.01393054,0.00000582686,0.0001100043,0.0001623447,0.00007762533,0.00210061,0.9678825,0.00005812981,0.001205268,0.00002139176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977701,0.0004833595,0.001158742,0.00006284712,0.00001568182,0.00002322296,0.000207271,0.00006343499,0.0002153067],"genre_scores_gemma":[0.9950927,0.0006198403,0.001733067,0.00007354326,0.00002009689,0.00006666619,0.0003867784,0.00002474464,0.001982524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001142395,"threshold_uncertainty_score":0.003065169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1661766705906484,"score_gpt":0.4648787118982912,"score_spread":0.2987020413076427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}