{"id":"W1596920897","doi":"10.1111/j.1365-2249.2004.02495.x","title":"Down-regulation of CXCR-4 and CCR-5 expression by interferon-<i>γ</i>is associated with inhibition of chemotaxis and human immunodeficiency virus (HIV) replication but not HIV entry into human monocytes","year":2004,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Chemokine; Biology; Chemotaxis; CXCR4; Viral replication; Interferon gamma; Chemokine receptor; Immunology; Monocyte; Virus; Interferon; Chemokine receptor CCR5; Cytokine; Virology; Receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003413814,0.0002525071,0.000576398,0.0001113916,0.0002800409,0.00001328856,0.0001541723,0.0004268668,0.0001667334],"category_scores_gemma":[0.00009751765,0.0002125433,0.00009169627,0.000101259,0.001712644,0.0001681398,0.0002590498,0.0003254636,0.00003109361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393468,"about_ca_system_score_gemma":0.00004264773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005280414,"about_ca_topic_score_gemma":0.00001435068,"domain_scores_codex":[0.9978,0.0003105786,0.0008819137,0.0006156291,0.00007972335,0.0003121567],"domain_scores_gemma":[0.998679,0.0001800789,0.0004990548,0.0004982694,0.0001022595,0.00004132258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009842516,0.001926137,0.004083575,0.00001418967,0.0002497142,0.000001806361,0.001098077,4.315299e-7,0.9901494,0.0003407014,0.000200293,0.0009514649],"study_design_scores_gemma":[0.006959861,0.00371777,0.03438878,0.0001670357,0.00003815488,0.00001612963,0.0006591669,8.652287e-7,0.9535423,0.0002326039,0.0001039224,0.0001734083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933228,0.00559915,0.00007339004,0.0001599243,0.00005267904,0.0004543969,0.000130175,0.00004046341,0.0001669553],"genre_scores_gemma":[0.9980746,0.0002769079,0.0001113267,0.0000464443,0.000007717166,0.00006815771,0.001158018,0.00002060047,0.0002362534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03660705,"threshold_uncertainty_score":0.8667265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250724052637661,"score_gpt":0.3362719915982219,"score_spread":0.3111995863344558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}