{"id":"W1597214954","doi":"10.1155/2012/538452","title":"The Impact of Farnesoid X Receptor Activation on Intestinal Permeability in Inflammatory Bowel Disease","year":2012,"lang":"en","type":"review","venue":"Canadian Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Farnesoid X receptor; Intestinal permeability; Proinflammatory cytokine; Inflammatory bowel disease; Barrier function; Inflammation; Immunology; Tumor necrosis factor alpha; Transcription factor; Intestinal mucosa; Cancer research; Medicine; Internal medicine; Biology; Nuclear receptor; Disease; Cell biology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004204971,0.0007957618,0.001168356,0.001806931,0.000240552,0.000646952,0.0006300612,0.001019304,0.002452586],"category_scores_gemma":[0.0004983629,0.0002036136,0.0003145297,0.001801959,0.0004674454,0.0008367526,0.0004955709,0.001169544,0.00162343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005783359,"about_ca_system_score_gemma":0.0007860104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001228251,"about_ca_topic_score_gemma":0.002240326,"domain_scores_codex":[0.9998734,0.0000221812,0.00001964581,0.00002193085,0.00005016093,0.00001265547],"domain_scores_gemma":[0.9997787,0.0000867985,0.00003489734,0.000005727964,0.00006468835,0.00002918751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001184788,0.00005161002,0.0002604679,0.01152896,0.00006349552,0.000331135,0.00004962823,0.0002750846,0.001814249,0.001948049,0.02205971,0.961499],"study_design_scores_gemma":[0.00004061205,0.0001658362,0.00270611,0.003448323,0.0001406496,0.003574364,0.00009280477,0.0001056164,0.0008753397,0.001772451,0.9870505,0.00002725582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000983833,0.9990748,0.00005709186,0.0001543884,0.000108452,0.000001893285,0.000007556439,0.000003581551,0.0004939049],"genre_scores_gemma":[0.0006363885,0.9987753,0.00008021894,0.00007960059,0.0001035749,0.000002892447,0.00001176478,6.655516e-7,0.0003095919],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002452586,"threshold_uncertainty_score":0.008204699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682060439006611,"score_gpt":0.2754312187735402,"score_spread":0.2586106143834741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}