{"id":"W1598052913","doi":"10.2144/00295st04","title":"Establishment and Chimera Analysis of 129/SvEv- and C57BL/6-Derived Mouse Embryonic Stem Cell Lines","year":2000,"lang":"en","type":"article","venue":"BioTechniques","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Kidney Foundation of Canada; School of Medicine, New York University; York University; Howard Hughes Medical Institute","keywords":"Chimera (genetics); Embryonic stem cell; Germline; Biology; Blastocyst; Cell culture; Genetics; Cell biology; Stem cell; Embryo; Gene targeting; Gene; Mutant; Cell; Molecular biology; Embryogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043721,0.0001625152,0.0002612736,0.0001751956,0.00005456736,0.00003652421,0.0001553315,0.0002160655,0.00004366626],"category_scores_gemma":[0.000005600587,0.0001467531,0.0000860643,0.0002360645,0.0001379089,0.000006704997,0.0001377667,0.00008988599,0.000001471413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001010632,"about_ca_system_score_gemma":0.00003006698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009703903,"about_ca_topic_score_gemma":0.00002518438,"domain_scores_codex":[0.9989405,0.00007724075,0.0002107063,0.0003956362,0.0001553162,0.0002205606],"domain_scores_gemma":[0.9993965,0.00001289587,0.00006844811,0.0003671876,0.00005774653,0.0000972074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006225762,0.00006309546,0.0008425691,0.00005019498,0.0001410477,0.000001961404,0.00003500191,0.0000054463,0.987874,0.000004840485,0.0003336128,0.01058592],"study_design_scores_gemma":[0.000188541,0.0002534087,0.001865871,0.00001067289,0.0001166221,0.000002638168,0.0000262162,0.0002662152,0.9886119,0.000005545336,0.008493331,0.0001590186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953325,0.003018966,0.0005224649,0.0001356885,0.000007295529,0.0002567124,0.00005486859,0.00003498588,0.0006364525],"genre_scores_gemma":[0.9817852,0.01251415,0.002352655,0.00006144976,0.0000292517,0.00002221983,0.00008048635,0.0000195868,0.003134963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01354732,"threshold_uncertainty_score":0.5984419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009486442013895079,"score_gpt":0.2527948747900504,"score_spread":0.2433084327761553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}