{"id":"W1598052913","doi":"10.2144/00295st04","title":"Establishment and Chimera Analysis of 129/SvEv- and C57BL/6-Derived Mouse Embryonic Stem Cell Lines","year":2000,"lang":"en","type":"article","venue":"BioTechniques","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Kidney Foundation of Canada; School of Medicine, New York University; York University; Howard Hughes Medical Institute","keywords":"Chimera (genetics); Embryonic stem cell; Germline; Biology; Blastocyst; Cell culture; Genetics; Cell biology; Stem cell; Embryo; Gene targeting; Gene; Mutant; Cell; Molecular biology; Embryogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00111809,0.0004678137,0.0004896174,0.001438689,0.0004977126,0.0005172113,0.0007725662,0.0005923093,0.002939217],"category_scores_gemma":[0.0006467954,0.0004871431,0.0006187098,0.0005127831,0.0003831858,0.0003398547,0.0007966927,0.001853269,0.00116585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000402323,"about_ca_system_score_gemma":0.0003686125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009149,"about_ca_topic_score_gemma":0.001381184,"domain_scores_codex":[0.9990054,0.0001180852,0.0001798849,0.0001985331,0.0003561843,0.0001420024],"domain_scores_gemma":[0.9993252,0.0001097175,0.0001418843,0.0001498883,0.0001034477,0.0001699562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231879,0.00008158336,0.0005012828,0.00003389348,0.00001589884,0.0001239842,0.00007326467,0.000111558,0.9965137,0.0006151074,0.00006904187,0.001737542],"study_design_scores_gemma":[0.00003855232,0.0003855947,0.005927967,0.00002701291,0.00007018606,0.001175065,0.00007420291,0.001679287,0.9803439,0.000179985,0.01007783,0.0000203227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.898827,0.00146812,0.0849607,0.0001890513,0.000134016,0.001461014,0.005157086,0.0006374837,0.00716541],"genre_scores_gemma":[0.8554145,0.00265292,0.1098774,0.0001999605,0.00003230149,0.001687334,0.01086358,0.0008514227,0.01842058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939217,"threshold_uncertainty_score":0.00983268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009486442013895079,"score_gpt":0.2527948747900504,"score_spread":0.2433084327761553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}