{"id":"W1598102702","doi":"10.1002/hep.27695","title":"Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n‐3 and n‐6 polyunsaturated fatty acids","year":2015,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":341,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Guelph; Public Health Ontario; University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Canadian Liver Foundation; American Gastroenterological Association; American College of Gastroenterology","keywords":"Polyunsaturated fatty acid; FADS2; Nonalcoholic fatty liver disease; Gene expression; Biology; Steatosis; Internal medicine; Endocrinology; Fatty acid metabolism; Docosahexaenoic acid; Fatty liver; Steatohepatitis; Metabolism; Fatty acid; Biochemistry; Gene; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112376,0.0003272177,0.0006364716,0.0001722216,0.00006359925,0.00002315803,0.00007886757,0.000162961,0.0001422005],"category_scores_gemma":[0.0001550405,0.0002381831,0.00008154187,0.0002735597,0.0001641184,0.0001250694,0.00007833525,0.0001828757,0.00005428864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002556923,"about_ca_system_score_gemma":0.0003108533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004357504,"about_ca_topic_score_gemma":0.0001925558,"domain_scores_codex":[0.9981105,0.0002147527,0.0003310822,0.0005546528,0.0003304497,0.0004585048],"domain_scores_gemma":[0.9984546,0.0001126148,0.000135349,0.0003975352,0.000170423,0.000729482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001356844,0.00140304,0.992567,0.00005582203,0.0001963412,0.002571004,0.0005339101,0.000001604088,0.0003468913,0.00001204675,0.0006749644,0.0002805002],"study_design_scores_gemma":[0.007539961,0.0006224443,0.9814997,0.0003608084,0.0005488414,0.00008509065,0.00003440577,0.005419035,0.003378875,0.0000963953,0.0001242695,0.000290152],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954844,0.002396601,0.00002857246,0.0009945249,0.0001319943,0.0007077739,0.00007992858,0.00007012412,0.0001060572],"genre_scores_gemma":[0.9967749,0.0003403817,0.000289148,0.001991214,0.00004668704,0.0001611669,0.0002821509,0.0000393869,0.00007498406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01106731,"threshold_uncertainty_score":0.9712825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03083810203392703,"score_gpt":0.2700296045029028,"score_spread":0.2391915024689757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}