{"id":"W1598195946","doi":"10.4049/jimmunol.165.5.2841","title":"Islet-Specific Expression of IL-10 Promotes Diabetes in Nonobese Diabetic Mice Independent of Fas, Perforin, TNF Receptor-1, and TNF Receptor-2 Molecules","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Accelerated Innovation Research Initiative Turning Top Science and Ideas into High-Impact Values","keywords":"Insulitis; NOD mice; Perforin; Nod; Pancreatic islets; Endocrinology; Internal medicine; Diabetes mellitus; Tumor necrosis factor alpha; Receptor; Medicine; Immunology; Islet; Biology; CD8; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006208271,0.0001838272,0.0004079748,0.000108272,0.00004961941,0.000009632428,0.0003885148,0.0002307109,0.0002881151],"category_scores_gemma":[0.000104381,0.0001346518,0.0001119265,0.0001304743,0.0002848805,0.00001429047,0.0001137149,0.0002747129,0.000005681923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001915901,"about_ca_system_score_gemma":0.00005327863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001418489,"about_ca_topic_score_gemma":0.000004069756,"domain_scores_codex":[0.9984242,0.0003306396,0.00061196,0.0001656043,0.0001624791,0.0003050969],"domain_scores_gemma":[0.9989707,0.00008150614,0.0004918666,0.0002522297,0.0001624872,0.0000411599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003199172,0.0002342472,0.004148911,0.00002582683,0.0001247889,6.026661e-7,0.00025943,0.00005266819,0.9754614,0.000009722624,0.0005270629,0.01883546],"study_design_scores_gemma":[0.001412461,0.001278723,0.008059443,0.0001748014,0.00003315429,0.000006019064,0.000721423,0.00001188002,0.9830433,0.0001636546,0.004934018,0.0001611114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829183,0.01637218,0.00000678007,0.0001854478,0.0001129238,0.0001325301,0.00002106546,0.000002454376,0.0002483803],"genre_scores_gemma":[0.9884017,0.01107245,0.0002093325,0.00003159074,0.00005283037,0.000004031609,0.00001652779,0.00002101942,0.000190482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01867435,"threshold_uncertainty_score":0.5490942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004843364551926393,"score_gpt":0.2012912900680039,"score_spread":0.1964479255160776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}