{"id":"W1599148944","doi":"10.1038/nm0901-1057","title":"Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes","year":2001,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":599,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials; Diabetes Canada","funders":"Sanofi","keywords":"Insulitis; Natural killer T cell; NOD mice; Immunology; Nod; Autoimmunity; CD1D; Type 1 diabetes; Pancreatic islets; Immune system; Medicine; Biology; Endocrinology; T cell; Islet; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451327,0.0001214732,0.00023545,0.0000665933,0.00006159128,0.000001791473,0.00008277177,0.0002019778,0.0005553294],"category_scores_gemma":[0.0001454947,0.00006754157,0.00003368433,0.0001576774,0.0001940958,0.00006251618,0.0000182074,0.0003790015,0.000008700602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003454856,"about_ca_system_score_gemma":0.00001808719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008693401,"about_ca_topic_score_gemma":0.000002733188,"domain_scores_codex":[0.9993297,0.0001199248,0.0002440754,0.0001347719,0.00004818571,0.0001233398],"domain_scores_gemma":[0.9992818,0.0002290084,0.0001997334,0.0001777571,0.0001036483,0.000008076193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003358468,0.0001047131,0.002547866,0.00001461035,0.0001333152,1.443519e-7,0.0004041991,6.168072e-7,0.9463201,0.00001623611,0.03809049,0.01203188],"study_design_scores_gemma":[0.001391985,0.0008502188,0.03017046,0.0001737827,0.00006920032,0.00001057204,0.0002020795,0.00001782253,0.7429122,0.000019236,0.2241056,0.00007681843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746388,0.01831889,0.000007061709,0.0009941878,0.005330066,0.0002050311,0.000002357125,0.00001399524,0.0004895588],"genre_scores_gemma":[0.9844289,0.001695669,0.000005173278,0.000206955,0.00002359579,0.000004763428,0.000197927,0.000006282862,0.01343078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2034079,"threshold_uncertainty_score":0.6080467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006971206129580879,"score_gpt":0.2471940393930488,"score_spread":0.240222833263468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}