{"id":"W1600326137","doi":"10.1186/ar1401","title":"Activation of peroxisome proliferator-activated receptor γ inhibits IL-1β-induced mPGES-1 expression in human synovial fibroblasts by interfering with Egr-1","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Troglitazone; Transactivation; Peroxisome proliferator-activated receptor; Electrophoretic mobility shift assay; Thiazolidinedione; Receptor; Molecular biology; Chemistry; Transcription factor; Reporter gene; Ligand (biochemistry); Cell biology; Gene expression; Biology; Gene; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008285454,0.0002261775,0.0004479938,0.0005228961,0.000173478,0.00003778277,0.0001328297,0.0002211783,0.0001155725],"category_scores_gemma":[0.0003543467,0.0001936349,0.00005131438,0.0006783666,0.0001658676,0.0004026414,0.0001053765,0.0008666798,0.00002919775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540504,"about_ca_system_score_gemma":0.0003084187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002166428,"about_ca_topic_score_gemma":0.00009012914,"domain_scores_codex":[0.9972206,0.0002611032,0.0004555346,0.0004676408,0.0009682992,0.0006267911],"domain_scores_gemma":[0.9988326,0.0001245367,0.0001027972,0.0003437031,0.0003507284,0.0002456367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001252959,0.0003474478,0.003448173,0.0002308943,0.00001815674,0.00005603555,0.001135191,0.00001481809,0.9890625,0.00003619355,0.0002598897,0.004137759],"study_design_scores_gemma":[0.005869741,0.003060529,0.002413785,0.005215317,0.000002137142,0.00002248439,0.000304309,0.00001091026,0.9826778,0.00003110317,0.00020642,0.0001854183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980232,0.00008264981,0.00002906096,0.0002373623,0.00005893724,0.001197341,0.00001248712,0.0000595104,0.0002995181],"genre_scores_gemma":[0.9992071,0.00006149503,0.0001619973,0.00002289669,0.0001815209,0.000180639,0.0000612877,0.00005982817,0.00006318531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006384638,"threshold_uncertainty_score":0.7896203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754826526469361,"score_gpt":0.3206438291517705,"score_spread":0.2930955638870769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}