{"id":"W1600326137","doi":"10.1186/ar1401","title":"Activation of peroxisome proliferator-activated receptor γ inhibits IL-1β-induced mPGES-1 expression in human synovial fibroblasts by interfering with Egr-1","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Troglitazone; Transactivation; Peroxisome proliferator-activated receptor; Electrophoretic mobility shift assay; Thiazolidinedione; Receptor; Molecular biology; Chemistry; Transcription factor; Reporter gene; Ligand (biochemistry); Cell biology; Gene expression; Biology; Gene; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006223726,0.0004582978,0.0003643567,0.0003924731,0.0002103266,0.0004406985,0.0003127154,0.0002989056,0.003308131],"category_scores_gemma":[0.0002015048,0.0001780046,0.0005974108,0.0002459138,0.0003372204,0.000193351,0.0002732437,0.0008127111,0.001015731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395379,"about_ca_system_score_gemma":0.0003087519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004987005,"about_ca_topic_score_gemma":0.0005286096,"domain_scores_codex":[0.9995373,0.0001202404,0.00006629036,0.00007524939,0.0000916578,0.0001093153],"domain_scores_gemma":[0.9998668,0.00004571807,0.00003024043,0.0000218284,0.00001393708,0.00002136918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006621453,0.0002694017,0.0002818184,0.0002874091,0.00002491434,0.00007399177,0.00009821706,0.0001680418,0.9943873,0.0001385063,0.0003353977,0.003273005],"study_design_scores_gemma":[0.0001883583,0.002614521,0.004303212,0.00004327691,0.00006584288,0.000306522,0.0001384391,0.001502229,0.9846452,0.0001072285,0.006073495,0.00001164952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795363,0.009455077,0.005640582,0.0006763373,0.0003449509,0.00010056,0.000882866,0.0001603799,0.0032029],"genre_scores_gemma":[0.9852355,0.005296078,0.0044686,0.0002174343,0.00005379371,0.0001931631,0.001310965,0.00002486811,0.003199686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003308131,"threshold_uncertainty_score":0.01106673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754826526469361,"score_gpt":0.3206438291517705,"score_spread":0.2930955638870769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}