{"id":"W1600365609","doi":"10.1182/blood-2015-01-621664","title":"International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with &gt;30% blasts","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; Princess Margaret Cancer Centre; CancerCare Manitoba","funders":"","keywords":"Azacitidine; Medicine; Internal medicine; Hypomethylating agent; Phases of clinical research; Complete remission; Oncology; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261652,0.0001694103,0.0003141691,0.0002525866,0.00002275736,0.00001314977,0.0001628341,0.00005600185,0.000526542],"category_scores_gemma":[0.0001413021,0.0001248056,0.00003011706,0.0002836834,0.00009718516,0.0001086488,0.00007820658,0.0002323035,0.00002165496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004985,"about_ca_system_score_gemma":0.000449096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001375865,"about_ca_topic_score_gemma":0.0001461515,"domain_scores_codex":[0.998026,0.00006498583,0.0002826683,0.0003227404,0.001056536,0.0002471099],"domain_scores_gemma":[0.9984392,0.00007580867,0.0001242518,0.0002886075,0.0008639288,0.0002081963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003349852,0.01613339,0.9712701,0.00006164056,0.0004570967,0.0006750912,0.004045264,0.00002779384,0.00009737512,0.00001641992,0.003370305,0.0004956588],"study_design_scores_gemma":[0.2885272,0.01370056,0.6884015,0.0004202791,0.0002460176,0.00003931208,0.005803185,0.0000792838,0.0008877475,0.000003208984,0.00165394,0.0002377778],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968882,0.00002880038,0.00001896336,0.000151959,0.00004461292,0.001174736,0.000162423,0.00002465885,0.001505708],"genre_scores_gemma":[0.9981484,0.000002962564,0.0006093503,0.00005822153,0.00009477699,0.0001237099,0.0006153397,0.00003300754,0.0003142784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2851773,"threshold_uncertainty_score":0.5765266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641405087413181,"score_gpt":0.2939353942663254,"score_spread":0.2775213433921936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}