{"id":"W1600502939","doi":"10.1593/neo.91122","title":"Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Sontag Foundation; National Institute of Neurological Disorders and Stroke; Pediatric Brain Tumor Foundation","keywords":"Biology; Medulloblastoma; Demethylating agent; KLF4; Epigenetics; Cancer research; Bisulfite sequencing; CpG site; Methylation; DNA methylation; Molecular biology; Genetics; Transcription factor; Gene; Gene expression; SOX2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009765823,0.0001558871,0.0001711473,0.0001402746,0.00003110876,0.00001655008,0.0001851666,0.0002460286,0.00009083944],"category_scores_gemma":[0.0001757957,0.0001545195,0.00004193666,0.0001556499,0.0001377057,0.000005694993,0.0001273391,0.0002308488,0.00001128865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001427226,"about_ca_system_score_gemma":0.0001229526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001255527,"about_ca_topic_score_gemma":0.001285094,"domain_scores_codex":[0.9988508,0.00005792309,0.0002485756,0.0003473526,0.0002064752,0.0002888665],"domain_scores_gemma":[0.9993328,0.00003324623,0.00007738042,0.0003592469,0.00008628766,0.0001110001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005083114,0.00004569342,0.2144153,0.0000228765,0.00001071663,0.000002680601,0.00006913386,0.000008255279,0.779545,0.00001110603,0.00008844409,0.005729997],"study_design_scores_gemma":[0.0004221213,0.0002098957,0.5537313,0.000007633826,0.000002995957,0.00001864249,0.00003869048,0.00007153102,0.4424058,0.00004064966,0.00293374,0.0001170949],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988719,0.0001352816,0.0001761789,0.00006561067,0.0001784002,0.0002293664,0.00002020951,0.000007435388,0.0003156773],"genre_scores_gemma":[0.9987475,0.00008978715,0.0007814307,0.00003187548,0.00008170649,0.00001770044,0.0000204573,0.00002644831,0.0002031549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.339316,"threshold_uncertainty_score":0.6301121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006586624034672373,"score_gpt":0.2554760718223895,"score_spread":0.2488894477877171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}