{"id":"W1600502939","doi":"10.1593/neo.91122","title":"Genetic and Epigenetic Inactivation of Kruppel-like Factor 4 in Medulloblastoma","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Sontag Foundation; National Institute of Neurological Disorders and Stroke; Pediatric Brain Tumor Foundation","keywords":"Biology; Medulloblastoma; Demethylating agent; KLF4; Epigenetics; Cancer research; Bisulfite sequencing; CpG site; Methylation; DNA methylation; Molecular biology; Genetics; Transcription factor; Gene; Gene expression; SOX2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007505815,0.0001870315,0.0001869267,0.0004105195,0.0001257882,0.0001444794,0.0001220187,0.0001140814,0.0004980866],"category_scores_gemma":[0.0002562177,0.0001144908,0.0001664468,0.0001804771,0.0002072162,0.00007563727,0.000142921,0.0001721636,0.0001818649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002921807,"about_ca_system_score_gemma":0.0002008042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001615506,"about_ca_topic_score_gemma":0.002343292,"domain_scores_codex":[0.9999306,0.000007708165,0.000007767509,0.00001533619,0.0000233622,0.00001520955],"domain_scores_gemma":[0.9999096,0.00001912859,0.00003119486,0.00001387625,0.000008356815,0.00001780203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009520732,0.00001089981,0.004122253,0.00002306064,0.00001182274,0.000292778,0.00001692993,0.0001599677,0.9921708,0.00008370793,0.00002908265,0.00298355],"study_design_scores_gemma":[0.00002681227,0.0002484946,0.1174841,0.000009221449,0.0001005903,0.005853413,0.00008817476,0.002059188,0.8699523,0.0002983153,0.003865318,0.00001399613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976906,0.0005646673,0.001161952,0.00002621675,0.00000425229,0.000005790829,0.0001743988,0.00004505227,0.0003270209],"genre_scores_gemma":[0.9978376,0.0004917555,0.0009727372,0.00001195813,0.000003156538,0.000004887977,0.0002374287,0.000008292611,0.0004321543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615506,"threshold_uncertainty_score":0.003212214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006586624034672373,"score_gpt":0.2554760718223895,"score_spread":0.2488894477877171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}