{"id":"W1600908488","doi":"10.1371/journal.pone.0130177","title":"Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer’s Disease: From Early to Advanced Pathological Stages","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Inselspital, Universitätsspital Bern; Canadian Institutes of Health Research; University of Bern; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Wakefulness; Non-rapid eye movement sleep; Alzheimer's disease; Neuroscience; Prazosin; Amyloid precursor protein; Endocrinology; Psychology; Internal medicine; Medicine; Pharmacology; Antagonist; Electroencephalography; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000332022,0.001579277,0.0008965117,0.001571337,0.0006278863,0.0005514018,0.0006978695,0.001218958,0.002305331],"category_scores_gemma":[0.000147564,0.0005457199,0.0009019588,0.0005153455,0.0007961243,0.0005528229,0.0003381224,0.00255328,0.0006343056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006419726,"about_ca_system_score_gemma":0.0004106864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001774951,"about_ca_topic_score_gemma":0.00390392,"domain_scores_codex":[0.9996299,0.00003554472,0.00006266544,0.0001208971,0.00007991639,0.0000710142],"domain_scores_gemma":[0.9996409,0.00003149988,0.0001089062,0.0000366775,0.00004069854,0.0001412191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001632109,0.0009884509,0.0007538695,0.00008950812,0.00002390126,0.000462196,0.0001125503,0.0001217035,0.9937494,0.0001745237,0.0001680311,0.001723797],"study_design_scores_gemma":[0.001135386,0.01246348,0.03815523,0.0001042911,0.0002830642,0.003658273,0.0003270586,0.002680286,0.9307145,0.0005732158,0.009825827,0.00007941902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933292,0.0009188408,0.001763092,0.0002752222,0.00009091094,0.0002216098,0.001972046,0.0002218462,0.00120725],"genre_scores_gemma":[0.9657781,0.002321348,0.009273351,0.0003235409,0.00007789352,0.00132995,0.003799225,0.0001825231,0.01691414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002305331,"threshold_uncertainty_score":0.007712066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1948351225618224,"score_gpt":0.3077461205550736,"score_spread":0.1129109979932511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}