{"id":"W1601100097","doi":"10.1113/jphysiol.2014.279562","title":"The dynamic role of regulator of G‐protein signalling (RGS) proteins in partial agonism","year":2014,"lang":"en","type":"letter","venue":"The Journal of Physiology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Heterotrimeric G protein; Partial agonist; G protein; G protein-coupled receptor; GTPase-activating protein; Cell biology; Regulator of G protein signaling; Agonist; Chemistry; Biology; Neuroscience; Signal transduction; Pharmacology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003565729,0.0003545073,0.0004945415,0.0001770827,0.0001796982,0.0005562762,0.0002908239,0.0006223595,0.000978062],"category_scores_gemma":[0.0002946538,0.0001805716,0.000477699,0.0001233373,0.0006053566,0.0006007751,0.0004902395,0.0009572174,0.0003308554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398528,"about_ca_system_score_gemma":0.0002698447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001865216,"about_ca_topic_score_gemma":0.0002693538,"domain_scores_codex":[0.9997658,0.00004805962,0.00001584549,0.00004596779,0.00006625868,0.00005807871],"domain_scores_gemma":[0.9998517,0.00002444654,0.0000502383,0.00001634183,0.00002361411,0.00003374719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008017231,0.00004184976,0.001456225,0.0004430752,0.00004112274,0.0006341771,0.00011396,0.0002877896,0.9800134,0.002660237,0.0006924444,0.01281411],"study_design_scores_gemma":[0.0003303079,0.004653941,0.1820011,0.0003423305,0.0005774153,0.00990978,0.0008947934,0.007065467,0.7005765,0.01025138,0.08324447,0.0001525413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.9117394,0.05879093,0.01346997,0.003843051,0.0004667328,0.0001091824,0.0006195818,0.0002451706,0.01071604],"genre_scores_gemma":[0.9790859,0.0148871,0.002341765,0.0009513741,0.0001498928,0.00005138638,0.0002728305,0.00003141743,0.002228478],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.000978062,"threshold_uncertainty_score":0.003271937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131652508420957,"score_gpt":0.255084943091447,"score_spread":0.2437684180072374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}