{"id":"W1601200919","doi":"10.4049/jimmunol.179.5.2731","title":"Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Eye Institute; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"T cell; CD8; Cell biology; CD80; Cytotoxic T cell; Biology; Exosome; MHC class I; CTL*; Immune system; Dendritic cell; Immunology; Microvesicles; In vitro; CD40; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00411717,0.0005378688,0.0009521956,0.0006128694,0.00087116,0.00004016391,0.0007515199,0.0005776428,0.0004409036],"category_scores_gemma":[0.0007061642,0.000379721,0.0002711017,0.000356054,0.000520066,0.000269632,0.0003098095,0.001806188,0.00005519432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969003,"about_ca_system_score_gemma":0.0002737838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001323943,"about_ca_topic_score_gemma":0.000005405889,"domain_scores_codex":[0.9949458,0.001473279,0.001857938,0.0003276372,0.0001858643,0.001209428],"domain_scores_gemma":[0.9923106,0.004693475,0.001847214,0.0006867676,0.000398414,0.00006351099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02029809,0.0005097146,0.0006214757,0.00003370966,0.0004593952,0.0000431823,0.003920439,0.0004746389,0.970524,0.00001126219,0.0002363344,0.00286775],"study_design_scores_gemma":[0.009524059,0.00144027,0.09352117,0.000243816,0.0002067067,0.002772449,0.005133578,0.0000910375,0.8820536,0.000008922001,0.004564166,0.0004402822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.913129,0.08227731,0.0009721455,0.0003110935,0.002709173,0.0003444219,0.00002209055,0.00005917647,0.0001756197],"genre_scores_gemma":[0.9961942,0.001600577,0.0002597832,0.0002032626,0.0001119362,0.000002638353,0.00002987089,0.00007411354,0.001523626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0928997,"threshold_uncertainty_score":0.9998655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008726971521469527,"score_gpt":0.2377751297892709,"score_spread":0.2290481582678013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}