{"id":"W1601200919","doi":"10.4049/jimmunol.179.5.2731","title":"Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Eye Institute; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"T cell; CD8; Cell biology; CD80; Cytotoxic T cell; Biology; Exosome; MHC class I; CTL*; Immune system; Dendritic cell; Immunology; Microvesicles; In vitro; CD40; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000844098,0.0003278527,0.0002944107,0.0001236133,0.00007134026,0.000233498,0.0002093175,0.0003322522,0.000601616],"category_scores_gemma":[0.00006203292,0.00008953203,0.000171598,0.00006099134,0.0001507363,0.0002722356,0.0001951042,0.0003599581,0.000170523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494516,"about_ca_system_score_gemma":0.0001780401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001131262,"about_ca_topic_score_gemma":0.0001532711,"domain_scores_codex":[0.999925,0.0000139581,0.000006473382,0.00001550791,0.00001716121,0.00002192998],"domain_scores_gemma":[0.9999723,0.000003620711,0.000007697805,0.000002936899,0.000005648315,0.000007783124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531805,0.0000971464,0.0001255611,0.00008546593,0.000009186114,0.00008391117,0.000009201625,0.0003143566,0.9933445,0.0002212315,0.0001107002,0.005445435],"study_design_scores_gemma":[0.0001500758,0.001958946,0.00118523,0.00001469319,0.00006659268,0.0006290538,0.00002291939,0.005016967,0.982077,0.000155714,0.008712439,0.00001035241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844551,0.00251435,0.01114754,0.0001865463,0.0001330251,0.00008382935,0.0001049992,0.0001017323,0.001272707],"genre_scores_gemma":[0.990486,0.0010714,0.005148334,0.0001224587,0.00003620937,0.00007607743,0.0002491471,0.00001351235,0.002796792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000601616,"threshold_uncertainty_score":0.00201261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008726971521469527,"score_gpt":0.2377751297892709,"score_spread":0.2290481582678013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}