{"id":"W1601351893","doi":"10.1111/bph.12505","title":"Unexpectedly high affinity of a novel histamine<scp>H<sub>3</sub></scp>receptor antagonist,<scp>GSK239512</scp>,<i>in vivo</i>in human brain, determined using<scp>PET</scp>","year":2013,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Radioligand; In vivo; Receptor; Antagonist; Radioligand Assay; Histamine; Pharmacology; Chemistry; Population; Ex vivo; Receptor antagonist; In vitro; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585613,0.0002468129,0.0004835581,0.00009504287,0.00011983,0.0004047062,0.000173492,0.0003887231,0.001747524],"category_scores_gemma":[0.0004767571,0.000274695,0.0001937585,0.00008761597,0.0003613843,0.0002233842,0.00009705791,0.0004125277,0.0005031173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004185112,"about_ca_system_score_gemma":0.0002128029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002542813,"about_ca_topic_score_gemma":0.003511494,"domain_scores_codex":[0.9998517,0.00002841826,0.000006675381,0.0000656656,0.00002682531,0.00002072202],"domain_scores_gemma":[0.9998314,0.00004704437,0.00006578223,0.00001785176,0.0000174653,0.00002035145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006430445,0.00007732763,0.01739104,0.0002889584,0.0002429999,0.001145208,0.0001673858,0.000596828,0.9513422,0.0001110131,0.0004688403,0.02173786],"study_design_scores_gemma":[0.0005347818,0.009538028,0.5123295,0.00003026996,0.0008218511,0.01733667,0.0003075059,0.008902968,0.4454528,0.0004485253,0.004237331,0.00005966824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934743,0.002663553,0.0027946,0.00009152033,0.00001424739,0.00001989597,0.0003092971,0.00005580628,0.0005768494],"genre_scores_gemma":[0.9984896,0.0002986325,0.0006141831,0.00004979763,0.000009444059,0.00001127616,0.0001624075,0.00001419437,0.0003505616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002542813,"threshold_uncertainty_score":0.005846024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122952703059496,"score_gpt":0.2447168611126147,"score_spread":0.2324215908066651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}