{"id":"W1601351893","doi":"10.1111/bph.12505","title":"Unexpectedly high affinity of a novel histamine<scp>H<sub>3</sub></scp>receptor antagonist,<scp>GSK239512</scp>,<i>in vivo</i>in human brain, determined using<scp>PET</scp>","year":2013,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Radioligand; In vivo; Receptor; Antagonist; Radioligand Assay; Histamine; Pharmacology; Chemistry; Population; Ex vivo; Receptor antagonist; In vitro; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00115996,0.000742882,0.001986735,0.00108719,0.0003609836,0.000102858,0.001134275,0.0007564632,0.000762311],"category_scores_gemma":[0.001061731,0.0008872893,0.0005163159,0.0007845537,0.001036053,0.0005816189,0.0003438755,0.00196797,0.00009604589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004202895,"about_ca_system_score_gemma":0.0004955895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00220301,"about_ca_topic_score_gemma":0.001053004,"domain_scores_codex":[0.9936739,0.0009221602,0.002634847,0.0008309081,0.0002643201,0.001673929],"domain_scores_gemma":[0.9943593,0.002097255,0.002141654,0.0003094038,0.0008245292,0.0002679078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000418319,0.002393111,0.001305202,0.0001563858,0.0003555386,0.001016191,0.0005368486,0.0000931908,0.8732979,0.00005572158,0.1196934,0.001054764],"study_design_scores_gemma":[0.01578573,0.001128725,0.01068189,0.0003206328,0.0002658146,0.006419513,0.0008145604,0.00008646072,0.9081882,0.00007680729,0.05604227,0.0001894398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895052,0.004800076,0.000135301,0.0001434782,0.003058338,0.0008071382,0.0004045304,0.00006000706,0.001085925],"genre_scores_gemma":[0.9935235,0.0008461089,0.000714721,0.0008428023,0.0005240261,0.00005679425,0.0001129868,0.0001304307,0.00324868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06365108,"threshold_uncertainty_score":0.9993578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122952703059496,"score_gpt":0.2447168611126147,"score_spread":0.2324215908066651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}