{"id":"W1601595713","doi":"10.1111/j.1471-4159.2011.07644.x","title":"Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1","year":2011,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Deubiquitinating enzyme; Ubiquitin; Proteasome; HEK 293 cells; Amyloid precursor protein; Cell biology; Protein degradation; Ubiquitin ligase; Amyloid precursor protein secretase; Chemistry; Biology; Biochemistry; Gene; Alzheimer's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009672536,0.000105466,0.0002479455,0.00004158217,0.00003205096,0.0000101333,0.00006296031,0.00004892288,0.00005228341],"category_scores_gemma":[0.00008902643,0.00008258816,0.00007362494,0.0000516286,0.00008067596,0.0001034822,0.00001411197,0.0001891329,9.734466e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002115018,"about_ca_system_score_gemma":0.0001888818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004716366,"about_ca_topic_score_gemma":8.218138e-8,"domain_scores_codex":[0.9991111,0.0000223435,0.0002994905,0.0001072834,0.0003088998,0.000150956],"domain_scores_gemma":[0.9990761,0.00002896881,0.0003000191,0.00009322353,0.0001969505,0.0003047083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004451499,0.00162493,0.06482878,0.000949049,0.001815273,0.002493675,0.0002339381,4.884093e-7,0.9132027,0.000001883698,0.0009278186,0.009469993],"study_design_scores_gemma":[0.01245174,0.00198454,0.05845217,0.0007614126,0.002063948,0.005428018,0.0002757391,0.0006157205,0.9174593,0.00009124785,0.0001800708,0.0002361055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995294,0.003723691,0.0000844987,0.00009655567,0.00001295308,0.00007913898,0.00001444516,0.000005531582,0.0006891491],"genre_scores_gemma":[0.999543,0.00009193589,0.0001808602,0.00005573825,0.00006872725,0.000002156666,0.000005620431,0.00001195336,0.00004000025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009233888,"threshold_uncertainty_score":0.3367847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167332417069233,"score_gpt":0.2781155611475117,"score_spread":0.2564422369768193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}