{"id":"W1601709990","doi":"10.1038/nature13801","title":"Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":566,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Manchester Biomedical Research Centre; National Institutes of Health; National Center for Research Resources; Greater Manchester Comprehensive Local Research Network; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; CHIST-ERA; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; European Commission; Institut National de la Santé et de la Recherche Médicale","keywords":"ISG15; Interferon; Intracellular; Immunity; Biology; Innate immune system; Cell biology; Intracellular parasite; Interferon gamma; Inflammation; Immunology; Effector; Ubiquitin; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000332604,0.0004009402,0.0004793061,0.0003705091,0.0001666029,0.0005442887,0.0004898104,0.0005463277,0.002441802],"category_scores_gemma":[0.0002708376,0.0002254007,0.0004270023,0.0002067317,0.0006442954,0.0002151616,0.0002475348,0.001210372,0.0007798193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649368,"about_ca_system_score_gemma":0.0004535959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005595149,"about_ca_topic_score_gemma":0.0008050477,"domain_scores_codex":[0.9996389,0.00007411128,0.00004251671,0.00005655397,0.00005892612,0.0001290538],"domain_scores_gemma":[0.9996556,0.00005545581,0.00008497593,0.00008996809,0.00001677249,0.00009721442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002002186,0.0003722673,0.0005458268,0.00006369253,0.00004489431,0.0001091625,0.00002869197,0.0002846275,0.991753,0.0004393683,0.0003181658,0.004038106],"study_design_scores_gemma":[0.0003077363,0.001626026,0.002804067,0.00001283997,0.00004178575,0.0003002787,0.00004366548,0.000997701,0.991262,0.0001545484,0.002441799,0.000007498734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954652,0.0008139146,0.001051196,0.0002147833,0.0001660078,0.00003554897,0.0002979845,0.0001615614,0.001793844],"genre_scores_gemma":[0.9967944,0.0002246051,0.0007625767,0.00008771345,0.00002131372,0.00002510474,0.000415571,0.00002959749,0.001639124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002441802,"threshold_uncertainty_score":0.008168638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281485536991679,"score_gpt":0.3111259136766676,"score_spread":0.2983110583067508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}