{"id":"W1601709990","doi":"10.1038/nature13801","title":"Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":566,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Manchester Biomedical Research Centre; National Institutes of Health; National Center for Research Resources; Greater Manchester Comprehensive Local Research Network; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; CHIST-ERA; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; European Commission; Institut National de la Santé et de la Recherche Médicale","keywords":"ISG15; Interferon; Intracellular; Immunity; Biology; Innate immune system; Cell biology; Intracellular parasite; Interferon gamma; Inflammation; Immunology; Effector; Ubiquitin; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005486105,0.0001193928,0.0002007231,0.0001278054,0.00007631179,0.00003602185,0.0001012812,0.0007239359,0.00009748218],"category_scores_gemma":[0.0002167297,0.00009933772,0.00003834282,0.0001207933,0.00004205177,0.00009463164,0.00005108583,0.001084755,0.00004948183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056318,"about_ca_system_score_gemma":0.00002767502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008446276,"about_ca_topic_score_gemma":0.000005000989,"domain_scores_codex":[0.9988274,0.00008923543,0.0002301584,0.0002688685,0.0003963537,0.0001879631],"domain_scores_gemma":[0.9992629,0.00004843698,0.00008973382,0.0003800505,0.0001075182,0.0001113378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001771146,0.0001343322,0.087973,0.002051672,0.0001325101,0.00001399145,0.002023035,0.000001645136,0.8456188,0.01239254,0.01539176,0.03408954],"study_design_scores_gemma":[0.02141644,0.002912416,0.2474534,0.007579319,0.0005347392,0.006334532,0.001510169,0.03151365,0.3191021,0.0120293,0.3477674,0.001846557],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993526,0.000931019,0.0007045722,0.001022118,0.0001618682,0.0005472216,0.000002011843,0.0000854991,0.003019648],"genre_scores_gemma":[0.9956282,0.00002501781,0.0002955629,0.0001147169,0.0004090688,0.00002455965,0.00005546883,0.00002401387,0.003423383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5265167,"threshold_uncertainty_score":0.5583656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281485536991679,"score_gpt":0.3111259136766676,"score_spread":0.2983110583067508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}