{"id":"W1602209383","doi":"10.1002/0470846658.ch11","title":"Cartilage Matrix Resorption in Skeletogenesis","year":2001,"lang":"en","type":"review","venue":"Novartis Foundation symposium","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"","keywords":"Aggrecan; Extracellular matrix; Type II collagen; Chemistry; Collagen, type I, alpha 1; Chondrocyte; Cartilage; Collagenase; Cell biology; Resorption; Matrix metalloproteinase; Proteoglycan; Matrix Metalloproteinase 3; Cleavage (geology); Matrix (chemical analysis); Type I collagen; Proteolysis; Anatomy; Biochemistry; Endocrinology; Biology; Pathology; Osteoarthritis; Enzyme; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003740209,0.0007658555,0.001223233,0.001339586,0.0003869531,0.001072422,0.0006992512,0.001339408,0.003517478],"category_scores_gemma":[0.0002964499,0.0002342443,0.000255404,0.001102487,0.000782662,0.0008325406,0.0006219874,0.001087708,0.002898573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007465798,"about_ca_system_score_gemma":0.0006911522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008078915,"about_ca_topic_score_gemma":0.001794257,"domain_scores_codex":[0.9998246,0.00003633889,0.00002175275,0.00003686091,0.00006195299,0.00001846652],"domain_scores_gemma":[0.9998963,0.00003194702,0.00002460772,0.000005605425,0.00002849953,0.0000131357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001908799,0.0000745705,0.000350233,0.01225911,0.00006891957,0.001620259,0.0001486099,0.0003418389,0.009931665,0.008180325,0.02776737,0.9390661],"study_design_scores_gemma":[0.00004956526,0.0001982178,0.00221492,0.001835798,0.00007183643,0.008322379,0.0001310674,0.0001161389,0.003404265,0.004263226,0.9793683,0.00002419355],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002834042,0.9971136,0.0001853466,0.0001995508,0.0001906637,0.000004852862,0.00001085645,0.00001089715,0.002000893],"genre_scores_gemma":[0.003301037,0.9930997,0.0002498109,0.0003163534,0.0002321673,0.00001209112,0.00002652308,0.000002640007,0.002759597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003517478,"threshold_uncertainty_score":0.01176715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04804658017161188,"score_gpt":0.358005774545705,"score_spread":0.3099591943740931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}