{"id":"W1602439496","doi":"","title":"NSC101612 potently inhibits tumor cell growth and is a topoisomerase IIα catalytic inhibitor.","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Topoisomerase; Chinese hamster ovary cell; Molecular biology; DNA; Dithiothreitol; Biochemistry; Growth inhibition; Glutathione; K562 cells; DNA damage; Chemistry; Cell culture; PBR322; Cell growth; Biology; Apoptosis; Enzyme; Plasmid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007787244,0.0004086461,0.0003220034,0.0002556708,0.0001071604,0.0002174165,0.0001910325,0.0002172279,0.001793264],"category_scores_gemma":[0.00008311393,0.0001240905,0.0001597767,0.0003145714,0.0001416579,0.000113615,0.0001037241,0.0005449028,0.001016693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743634,"about_ca_system_score_gemma":0.0002654205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001207973,"about_ca_topic_score_gemma":0.002794697,"domain_scores_codex":[0.9999161,0.000008144261,0.000006230936,0.000009892419,0.0000434006,0.00001633648],"domain_scores_gemma":[0.9999404,0.000008419011,0.00001163793,0.00001062886,0.000008112584,0.00002074369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002243517,0.0001744922,0.0005655483,0.00007669624,0.00001978552,0.0001444841,0.00001111081,0.0001404054,0.9863071,0.00008647575,0.0007287787,0.01152079],"study_design_scores_gemma":[0.0002116792,0.002757265,0.016182,0.00001126418,0.00007118021,0.002714106,0.00002787194,0.001152647,0.9568431,0.00006883487,0.01995118,0.000008795463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778581,0.009038457,0.0016746,0.000305632,0.00009699724,0.000119299,0.001265912,0.000318862,0.009322141],"genre_scores_gemma":[0.978263,0.005844573,0.001671302,0.0001240746,0.00003298598,0.00007559588,0.00593829,0.00003192839,0.008018255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793264,"threshold_uncertainty_score":0.005999088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141291554845391,"score_gpt":0.312084855713111,"score_spread":0.290671940164657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}