{"id":"W1603001808","doi":"10.1002/jcph.247","title":"Pharmacokinetic characterization of baclofen in patients with chronic kidney disease: dose adjustment recommendations","year":2014,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; McGill University Health Centre; Université de Montréal; inVentiv Health Clinical","funders":"","keywords":"Renal function; Pharmacokinetics; Kidney disease; Cmax; Medicine; Urology; Creatinine; Baclofen; Internal medicine; Pharmacology; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008998589,0.0001132958,0.0004569386,0.00009057715,0.00002811385,0.000001767387,0.0001690073,0.00009132853,0.0008721768],"category_scores_gemma":[0.0002560533,0.00006020087,0.0001201495,0.0001902814,0.0002083011,0.00006070433,0.00003796397,0.0007213386,0.0000103507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002785554,"about_ca_system_score_gemma":0.0001852505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.763193e-7,"about_ca_topic_score_gemma":3.605554e-7,"domain_scores_codex":[0.9976239,0.0008161828,0.00106208,0.000112352,0.0002119493,0.0001734861],"domain_scores_gemma":[0.9981813,0.0005118233,0.0007175767,0.0001163625,0.0001698992,0.0003030139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08802191,0.01862732,0.5998668,0.0004650167,0.001865763,0.00006342702,0.0002910307,0.001850692,0.05622239,0.0001107239,0.0352618,0.1973532],"study_design_scores_gemma":[0.01834621,0.003716436,0.9588817,0.00009833939,0.0007570404,0.000005835425,0.000002397178,0.001170357,0.0002463639,0.00006081933,0.01664451,0.00006995664],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755411,0.0001016815,0.0001306154,0.02247033,0.001195173,0.0004094175,0.000008508946,0.000006922233,0.0001362212],"genre_scores_gemma":[0.9879552,0.002645241,0.00003950267,0.008828868,0.0004238609,0.000003722618,0.00002395281,0.00001285778,0.00006678669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.359015,"threshold_uncertainty_score":0.9549725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02620408836226334,"score_gpt":0.3602540680354392,"score_spread":0.3340499796731759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}