{"id":"W1603115247","doi":"10.1002/cncr.22553","title":"Upfront window trial of topotecan in previously untreated children and adolescents with poor prognosis metastatic osteosarcoma","year":2007,"lang":"en","type":"article","venue":"Cancer","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"National Cancer Institute","keywords":"Topotecan; Medicine; Carboplatin; Osteosarcoma; Internal medicine; Etoposide; Chemotherapy; Ifosfamide; Toxicity; Oncology; Surgery; Gastroenterology; Cisplatin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000361014,0.000444914,0.000911682,0.000153464,0.0002622786,0.0004720841,0.0004669302,0.0005745121,0.001829903],"category_scores_gemma":[0.0003662238,0.0001904607,0.0004182698,0.0002871981,0.0003069504,0.0003203307,0.0002434611,0.00159647,0.000220636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006649712,"about_ca_system_score_gemma":0.0009823157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140405,"about_ca_topic_score_gemma":0.005287397,"domain_scores_codex":[0.9998535,0.00006394894,0.000008020997,0.00002071508,0.000021028,0.00003290504],"domain_scores_gemma":[0.9996529,0.00006770778,0.00007538538,0.00001179695,0.00001352408,0.0001787534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4746529,0.02916647,0.1338479,0.001654686,0.001840192,0.004387783,0.001108122,0.006595848,0.05208827,0.001332843,0.01242327,0.2809016],"study_design_scores_gemma":[0.4139786,0.3392279,0.2086679,0.0003555495,0.001367409,0.004553035,0.0003509019,0.005192073,0.00955756,0.0005278533,0.01617003,0.00005108395],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970048,0.001784735,0.00007397198,0.000149165,0.00001927043,0.0001817098,0.0002199758,0.00001652567,0.0005499472],"genre_scores_gemma":[0.9948596,0.001806139,0.0005595561,0.0003571539,0.0000611578,0.0004144927,0.001035612,0.000008942052,0.0008973934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829903,"threshold_uncertainty_score":0.006121576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374535042929716,"score_gpt":0.2825378385184198,"score_spread":0.2687924880891226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}