{"id":"W1603362850","doi":"10.1002/9780470921920.edm004","title":"Sex Differences in Drug Metabolism","year":2012,"lang":"en","type":"other","venue":"Encyclopedia of Drug Metabolism and Interactions","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Drug metabolism; Cytochrome P450; Internal medicine; Endocrinology; Sexual dimorphism; Metabolism; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007527437,0.000804831,0.001589593,0.001176079,0.0001433723,0.00003226964,0.0005893288,0.0004764861,0.01373294],"category_scores_gemma":[0.00009776025,0.0007365773,0.0002903764,0.0004634692,0.0003937737,0.0002728817,0.0003042665,0.001826768,0.0002323742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002259433,"about_ca_system_score_gemma":0.000133337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244337,"about_ca_topic_score_gemma":0.0005602516,"domain_scores_codex":[0.9961728,0.000896257,0.001014001,0.0007093101,0.0003522495,0.0008553812],"domain_scores_gemma":[0.9977076,0.0004761638,0.0007176769,0.0004809165,0.00007881751,0.0005388402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001694825,0.001930615,0.009318469,0.0004370219,0.001331596,0.00002950019,0.009808726,0.000009394125,0.002647872,0.008226347,0.8765007,0.08959024],"study_design_scores_gemma":[0.001475253,0.000005154244,0.005448448,0.00008149586,0.0009902015,0.00001476448,0.0004839117,0.00005103453,0.002018809,0.0003777306,0.9883601,0.0006930825],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.03866715,0.09838531,0.00001823401,0.00038298,0.01337408,0.0007966232,0.000921202,0.0001580194,0.8472964],"genre_scores_gemma":[0.1135903,0.123352,0.000621408,0.0005618607,0.003962364,0.0002407858,0.0001158788,0.0004253862,0.75713],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1118594,"threshold_uncertainty_score":0.9995085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04545445368411434,"score_gpt":0.3721745819144328,"score_spread":0.3267201282303184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}