{"id":"W1603594222","doi":"10.1002/9783527610754.pp08","title":"The SH2 Domain: A Prototype for Protein Interaction Modules","year":2008,"lang":"en","type":"other","venue":"Protein Science Encyclopedia","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"SH2 domain; Phosphopeptide; Allosteric regulation; Domain (mathematical analysis); GRB2; Modular design; Computational biology; Chemistry; Computer science; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; Biology; Biochemistry; Phosphorylation; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304712,0.0004840175,0.000203431,0.0004603313,0.0001711634,0.0007440616,0.0004084344,0.0003367024,0.006668252],"category_scores_gemma":[0.00009081998,0.0001525341,0.0001511872,0.0004937252,0.0004237979,0.0009109201,0.0004315628,0.0005109865,0.002919216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820432,"about_ca_system_score_gemma":0.0002140361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002714534,"about_ca_topic_score_gemma":0.0002553215,"domain_scores_codex":[0.9999447,0.000007911045,0.000002603852,0.00001900947,0.00001899764,0.000006830024],"domain_scores_gemma":[0.9999768,0.000005143431,0.000002755489,0.000003875559,0.000005394178,0.000006127217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003489409,0.00005606168,0.0006898628,0.0009966249,0.000047862,0.001601601,0.0002037444,0.001081593,0.5717842,0.1002448,0.02767242,0.2952724],"study_design_scores_gemma":[0.00004109634,0.0001001179,0.004390921,0.0001223976,0.0000305035,0.003454335,0.0001075363,0.002275254,0.1040402,0.01776399,0.8676441,0.00002943023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.29858,0.193909,0.1514836,0.003691306,0.002872969,0.0003068564,0.005354154,0.00310794,0.3406942],"genre_scores_gemma":[0.5893043,0.04032357,0.06851343,0.001005666,0.0004729217,0.0001986205,0.01023433,0.000317997,0.2896292],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.006668252,"threshold_uncertainty_score":0.02230746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034990321468353,"score_gpt":0.2671430112152659,"score_spread":0.2567931080005824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}