{"id":"W1604554081","doi":"10.1111/j.1751-7176.2011.00438.x","title":"Safety and Tolerability of the Direct Renin Inhibitor Aliskiren in Combination With Angiotensin Receptor Blockers and Thiazide Diuretics: A Pooled Analysis of Clinical Experience of 12,942 Patients","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Hypertension","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Aliskiren; Medicine; Tolerability; Losartan; Valsartan; Diuretic; Combination therapy; Pharmacology; Internal medicine; Thiazide; Hyperkalemia; Chlorthalidone; Adverse effect; Urology; Renin–angiotensin system; Endocrinology; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01424224,0.001262513,0.005285817,0.00157874,0.0002555806,0.001907116,0.0006710102,0.0009455411,0.0009871442],"category_scores_gemma":[0.01615579,0.0007491733,0.01204686,0.002628886,0.0004258387,0.0009649598,0.0007731373,0.0007040929,0.0002236802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006431362,"about_ca_system_score_gemma":0.0004808057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008407977,"about_ca_topic_score_gemma":0.001382883,"domain_scores_codex":[0.986624,0.006835216,0.003142469,0.001590813,0.001574403,0.0002331223],"domain_scores_gemma":[0.9790187,0.00905408,0.008203465,0.001634291,0.001642867,0.0004466753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.07897654,0.0002836704,0.4271263,0.008143602,0.4348095,0.0004287411,0.0003498106,0.001908375,0.002567397,0.00006675301,0.001156718,0.04418254],"study_design_scores_gemma":[0.009586592,0.01289086,0.670755,0.0007573526,0.2977541,0.001457756,0.0003060347,0.002283177,0.001078357,0.0001863645,0.002775621,0.0001687753],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.843078,0.149729,0.002098743,0.0001590339,0.0001310058,0.0002674744,0.003296901,0.00005292077,0.001186849],"genre_scores_gemma":[0.9842644,0.01160268,0.0007630405,0.0001461321,0.0001577201,0.0001520342,0.002732239,0.00002258987,0.0001592038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01424224,"threshold_uncertainty_score":0.07532108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06486208004468556,"score_gpt":0.3322905842507609,"score_spread":0.2674285042060753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}