{"id":"W1605882793","doi":"10.1186/ar1383","title":"Synergistic interactions of proinflammatory cytokines with oncostatin M: production of active collagenases and implications for joint destruction","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Oncostatin M; Proinflammatory cytokine; STAT protein; Cell biology; Janus kinase; Collagenase; Chemistry; Signal transduction; Cartilage; Activator (genetics); Matrix metalloproteinase; Tumor necrosis factor alpha; Downregulation and upregulation; Cytokine; Molecular biology; Biology; Receptor; Immunology; STAT3; Interleukin 6; Biochemistry; Inflammation; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719804,0.00005768159,0.0000903684,0.00008436224,0.0001139432,0.00000785106,0.00003978652,0.00003561688,0.000002043926],"category_scores_gemma":[0.0003024228,0.00005332201,0.00002355048,0.0001176897,0.0001731809,0.00001282898,0.00003241843,0.00005368154,3.535348e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000208959,"about_ca_system_score_gemma":0.0001856068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006973976,"about_ca_topic_score_gemma":0.0003240968,"domain_scores_codex":[0.9993824,0.00004123876,0.0001547715,0.0001983679,0.00009896098,0.0001242204],"domain_scores_gemma":[0.9991742,0.00001880892,0.00007400662,0.0001651094,0.0005278187,0.00004005773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001993748,0.00006716737,0.00007830682,0.0000472094,0.00002116722,3.674876e-7,0.0000702819,0.00003602155,0.9859136,0.001835348,0.0001170488,0.0116141],"study_design_scores_gemma":[0.0005233516,0.0009169609,0.001469975,0.0001295101,0.000005087781,0.0000277009,0.0003441513,0.000002655934,0.9920529,0.004075881,0.0003974902,0.00005439844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956318,0.0002824895,0.002885383,0.0002817448,0.00004037381,0.0007104406,0.00006212612,0.000004716627,0.0001009478],"genre_scores_gemma":[0.9956062,0.0003217149,0.003547887,0.000002983935,0.00009012558,0.0003211266,0.0000514185,0.00001082449,0.00004774217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01155971,"threshold_uncertainty_score":0.2174408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732085263163015,"score_gpt":0.3294107119932699,"score_spread":0.2920898593616397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}