{"id":"W1605882793","doi":"10.1186/ar1383","title":"Synergistic interactions of proinflammatory cytokines with oncostatin M: production of active collagenases and implications for joint destruction","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Oncostatin M; Proinflammatory cytokine; STAT protein; Cell biology; Janus kinase; Collagenase; Chemistry; Signal transduction; Cartilage; Activator (genetics); Matrix metalloproteinase; Tumor necrosis factor alpha; Downregulation and upregulation; Cytokine; Molecular biology; Biology; Receptor; Immunology; STAT3; Interleukin 6; Biochemistry; Inflammation; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001061243,0.0005199039,0.000465579,0.001059286,0.000212172,0.0007343678,0.0002345313,0.0004393508,0.001309643],"category_scores_gemma":[0.0008879395,0.0001783361,0.0005374316,0.0005893981,0.0005128659,0.000505577,0.0005185748,0.000516428,0.0003245002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000480084,"about_ca_system_score_gemma":0.000396081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003898892,"about_ca_topic_score_gemma":0.0005337305,"domain_scores_codex":[0.9993247,0.0002903341,0.00007770258,0.0000783516,0.0001445376,0.00008446046],"domain_scores_gemma":[0.9991633,0.000308295,0.0003309087,0.00003220148,0.00008434556,0.00008097637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00350855,0.0002852095,0.08557549,0.00296712,0.0004583081,0.006101332,0.0003586066,0.0007576579,0.6989021,0.004337322,0.003274866,0.1934733],"study_design_scores_gemma":[0.0003826211,0.005473688,0.3879508,0.0004986391,0.00109837,0.02987651,0.0009228677,0.002832578,0.5230764,0.004800355,0.0430149,0.00007226809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8023101,0.1629675,0.01673371,0.00428366,0.0004045678,0.0002231476,0.0009352759,0.0001546584,0.01198742],"genre_scores_gemma":[0.9631165,0.02576156,0.00790285,0.0003326266,0.0002612863,0.00006687785,0.0002836009,0.000008383775,0.002266228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309643,"threshold_uncertainty_score":0.005612493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732085263163015,"score_gpt":0.3294107119932699,"score_spread":0.2920898593616397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}