{"id":"W1606268630","doi":"10.1002/bdra.23273","title":"Genetic studies of <i>ANKRD6</i> as a molecular switch between Wnt signaling pathways in human neural tube defects","year":2014,"lang":"en","type":"article","venue":"Birth Defects Research Part A Clinical and Molecular Teratology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Neural tube; Biology; Signal transduction; Neuroscience; Computational biology; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002430106,0.0004810581,0.0003169227,0.0009354095,0.0002395352,0.0002204794,0.0002696023,0.0003735541,0.001060328],"category_scores_gemma":[0.0005952814,0.0001434809,0.0002912829,0.0005692182,0.0004052103,0.0001271844,0.0002320107,0.0002249399,0.0001761497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047598,"about_ca_system_score_gemma":0.0001141854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007566073,"about_ca_topic_score_gemma":0.0004905704,"domain_scores_codex":[0.9997075,0.000050742,0.00005939338,0.0000969017,0.00006003959,0.00002541729],"domain_scores_gemma":[0.9996837,0.00009459688,0.0001316052,0.00002031579,0.00002537922,0.00004438688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001876027,0.000158321,0.3003068,0.0003693929,0.000353957,0.01881291,0.000491912,0.001135015,0.6526905,0.0005109803,0.0003208651,0.02297326],"study_design_scores_gemma":[0.00009899219,0.0008359017,0.6493319,0.00006310108,0.0005313573,0.1107773,0.0002418504,0.002930899,0.2308643,0.0004366991,0.003843844,0.00004391785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977958,0.001045947,0.000683879,0.00002155609,0.000006052787,0.00001095036,0.0001492923,0.00001390161,0.0002724828],"genre_scores_gemma":[0.9988318,0.0002695277,0.000601854,0.00001192772,0.000005983298,0.000005126775,0.0001430142,0.000006002135,0.0001247263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060328,"threshold_uncertainty_score":0.003547192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09051872956598793,"score_gpt":0.4030470649828199,"score_spread":0.312528335416832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}