{"id":"W1606313206","doi":"10.1111/j.1742-4658.2010.07985.x","title":"Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions","year":2010,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"SH2 domain; Proto-oncogene tyrosine-protein kinase Src; SH3 domain; Tyrosine-protein kinase CSK; Cell biology; Tyrosine kinase; Protein kinase domain; Kinase; Phosphorylation; Biology; Chemistry; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716324,0.0003114764,0.0002042168,0.0001310382,0.0001686076,0.0002746523,0.0001383209,0.0002021464,0.000940136],"category_scores_gemma":[0.0001321955,0.00007766279,0.0002397216,0.0001012307,0.000215877,0.0002233329,0.0002524013,0.0002864859,0.0002260383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614038,"about_ca_system_score_gemma":0.0001618837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000633256,"about_ca_topic_score_gemma":0.0007367124,"domain_scores_codex":[0.9998617,0.00002342837,0.00001372803,0.000020552,0.00003630176,0.0000442742],"domain_scores_gemma":[0.9999081,0.00001635786,0.00003090406,0.000006410444,0.00001690692,0.00002132715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002922245,0.00002045057,0.001929626,0.00008321307,0.00002035905,0.0003340805,0.00004250371,0.0002786814,0.9902714,0.0004713004,0.00008295231,0.006173297],"study_design_scores_gemma":[0.0001211923,0.0004869015,0.1395446,0.00003740464,0.0000829768,0.003257639,0.0002509983,0.005307434,0.838973,0.001450576,0.01045276,0.00003452923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829932,0.01106941,0.003282738,0.0001607677,0.00003216681,0.00001533198,0.0001646593,0.00004192212,0.00223969],"genre_scores_gemma":[0.9965224,0.001999653,0.0004697404,0.00003738805,0.00001333967,0.000009026913,0.0001146168,0.000005016745,0.0008287876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000940136,"threshold_uncertainty_score":0.003145099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587304024338196,"score_gpt":0.2273137684211056,"score_spread":0.2197264643967675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}