{"id":"W1606523795","doi":"10.1016/s0076-6879(05)07032-1","title":"Protein‐Fragment Complementation Assays (PCA) in Small GTPase Research and Drug Discovery","year":2006,"lang":"en","type":"article","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Ontario Genomics","funders":"","keywords":"Effector; GTPase; Protein-fragment complementation assay; Drug discovery; Biology; Small GTPase; Computational biology; Complementation; Cell biology; GTPase-activating protein; Regulator; Signal transduction; G protein; Biochemistry; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01640366,0.0005298888,0.0008725443,0.001297974,0.0001764653,0.00006003673,0.0004971403,0.0007970633,0.00007298411],"category_scores_gemma":[0.00157474,0.0005567092,0.000118365,0.000888404,0.0008268065,0.00002824252,0.0005357426,0.00118472,0.000006365592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831293,"about_ca_system_score_gemma":0.0001810504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630453,"about_ca_topic_score_gemma":0.007806123,"domain_scores_codex":[0.9810629,0.01451416,0.00134285,0.001572372,0.0002686573,0.001239048],"domain_scores_gemma":[0.9971488,0.001447973,0.0003127824,0.000813824,0.0001459903,0.0001306401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000731237,0.0008236601,0.01343916,0.00009463309,0.0000315496,0.0002119402,0.0002141257,0.0009084452,0.9392248,0.02468055,0.0001857187,0.01945413],"study_design_scores_gemma":[0.00634103,0.001752035,0.1424178,0.000235235,0.00002285516,0.0001870074,0.000626991,0.0005143043,0.704223,0.1345254,0.008045408,0.001108906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.894865,0.001775425,0.09917451,0.000729839,0.0003449042,0.001583596,0.00002338743,0.00002978992,0.001473559],"genre_scores_gemma":[0.4285764,0.0000768953,0.5692695,0.0003273963,0.0001806329,0.0006591629,0.0001521827,0.00005960403,0.0006981574],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.470095,"threshold_uncertainty_score":0.9996884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07337286623194438,"score_gpt":0.4285353711713137,"score_spread":0.3551625049393694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}