{"id":"W1606797829","doi":"10.1002/9780470910085.ch7","title":"Use of Flow Cytometry to Study Drug Target Inhibition in Laboratory Animals and in Early‐Phase Clinical Trials","year":2010,"lang":"en","type":"other","venue":"","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"","keywords":"Flow cytometry; Drug; Pharmacology; Drug trial; Clinical trial; Medicine; Chemistry; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002645943,0.0008547568,0.0008371905,0.002451784,0.0004475813,0.001624348,0.0008560409,0.0007154986,0.009610123],"category_scores_gemma":[0.0008833589,0.0003588204,0.0005684762,0.00106422,0.0005429392,0.001223529,0.0005878645,0.001945551,0.003768497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001337983,"about_ca_system_score_gemma":0.0009558826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001160515,"about_ca_topic_score_gemma":0.002099202,"domain_scores_codex":[0.9991335,0.0002682401,0.00005022737,0.0001409794,0.0003194087,0.0000875645],"domain_scores_gemma":[0.999347,0.0002638327,0.00008669106,0.00008178381,0.0001703023,0.00005029202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008911,0.0008690281,0.002149808,0.0013415,0.0001153375,0.0001239538,0.0001127344,0.001048057,0.6502448,0.009917919,0.02619288,0.3069927],"study_design_scores_gemma":[0.0003467986,0.002714361,0.01108828,0.0003486005,0.0002446159,0.001465304,0.00009109342,0.004216693,0.6531865,0.006946936,0.3192343,0.0001164072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.08644283,0.210919,0.4816051,0.007932575,0.004089542,0.005163812,0.009071876,0.00500509,0.1897701],"genre_scores_gemma":[0.2194836,0.2411276,0.3832992,0.005845428,0.001423535,0.005435983,0.008137061,0.001032892,0.1342148],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.009610123,"threshold_uncertainty_score":0.03214902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1095874422944259,"score_gpt":0.4582945108898538,"score_spread":0.3487070685954279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}