{"id":"W1606994684","doi":"10.1016/s0076-6879(10)76008-0","title":"Production of Mouse Chimeras by Aggregating Pluripotent Stem Cells with Embryos","year":2010,"lang":"en","type":"article","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Chimera (genetics); Induced pluripotent stem cell; Biology; Germline; Embryonic stem cell; Stem cell; Genetics; Cell biology; Gene knockin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001099747,0.0010258,0.0007615779,0.001309538,0.0005147311,0.0008753084,0.001126017,0.001081305,0.004865335],"category_scores_gemma":[0.000467646,0.0009684362,0.001029564,0.0004752532,0.0005748574,0.0005928873,0.001138243,0.002508675,0.002246052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005107762,"about_ca_system_score_gemma":0.0003258012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005312263,"about_ca_topic_score_gemma":0.00075971,"domain_scores_codex":[0.9992865,0.00008030976,0.0001184825,0.0001712482,0.0002342491,0.0001092624],"domain_scores_gemma":[0.9990271,0.0001836073,0.0002755539,0.0002304929,0.00007292014,0.0002103097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152082,0.00002461304,0.0001490578,0.00005505051,0.0000230564,0.0001535365,0.00005474309,0.0002342233,0.996151,0.001173692,0.0001430779,0.001722883],"study_design_scores_gemma":[0.00002140683,0.00004523259,0.0003691151,0.000009525511,0.00003015089,0.0002004606,0.00001373591,0.0006515279,0.9931703,0.00009079408,0.005392341,0.000005358841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.815593,0.002962283,0.1512656,0.0009689585,0.0008653616,0.001296722,0.007270812,0.003372877,0.01640444],"genre_scores_gemma":[0.8537712,0.002644461,0.09039292,0.0003137488,0.00008820747,0.0008646226,0.004561278,0.00229532,0.04506817],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004865335,"threshold_uncertainty_score":0.01627624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462503721288901,"score_gpt":0.3603417724283627,"score_spread":0.3357167352154737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}