{"id":"W1607357356","doi":"10.1111/j.1600-0854.2006.00429.x","title":"The Lysosomal Trafficking of Acid Sphingomyelinase is Mediated by Sortilin and Mannose 6‐phosphate Receptor","year":2006,"lang":"en","type":"article","venue":"Traffic","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Acid sphingomyelinase; Mannose 6-phosphate; Biology; Mannose 6-phosphate receptor; Signal transducing adaptor protein; Cell biology; Ceramide; Lysosome; Clathrin; Receptor; Endocytosis; Immunoprecipitation; Mannose; Protein targeting; Endosome; Transport protein; Glycoprotein; Membrane protein; Biochemistry; Signal transduction; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906748,0.0002262663,0.0003631643,0.0000889117,0.0002189467,0.00004488767,0.0001940548,0.0001463291,0.0001935449],"category_scores_gemma":[0.0001668518,0.0001636712,0.0001152321,0.000405133,0.0003636935,0.00008787985,0.00005509811,0.0003079164,0.00006675873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005597114,"about_ca_system_score_gemma":0.0001029192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036252,"about_ca_topic_score_gemma":0.00006847958,"domain_scores_codex":[0.9979404,0.00006872834,0.0004964515,0.0003709807,0.0006002339,0.0005232699],"domain_scores_gemma":[0.999036,0.0001649434,0.0001361456,0.0003428369,0.0001477555,0.0001723608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00462649,0.002542563,0.02138803,0.0009586635,0.0005747859,0.0003124005,0.005348843,0.0002737966,0.4563449,0.0004005834,0.1455962,0.3616327],"study_design_scores_gemma":[0.03448824,0.004155655,0.08971076,0.0009124018,0.0007577356,0.0003176564,0.006573417,0.03847125,0.5863342,0.0002261048,0.2355681,0.002484479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843617,0.0117822,0.00001358161,0.002669062,0.00008064532,0.0005208793,0.00003899941,0.0001160486,0.000416853],"genre_scores_gemma":[0.9977015,0.0006369795,0.0001321302,0.0001354025,0.00009470038,0.00002447998,0.00008820932,0.00004679651,0.001139832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3591482,"threshold_uncertainty_score":0.6674318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073004698144704,"score_gpt":0.2610733892710921,"score_spread":0.2503433422896451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}