{"id":"W1607487366","doi":"10.1593/neo.08356","title":"Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas","year":2008,"lang":"en","type":"article","venue":"Neoplasia","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"University of California, San Francisco; Sontag Foundation","keywords":"Biology; Notch signaling pathway; Chromosome instability; HES1; Meningioma; Signal transduction; Cell biology; Cancer research; Context (archaeology); Genetics; Chromosome; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006517243,0.00009354539,0.00009261303,0.00002555878,0.00008547145,0.000004579913,0.00003669659,0.0001530913,0.00001245012],"category_scores_gemma":[0.00003674599,0.00008371052,0.00001433774,0.0001071903,0.00008515864,0.000006484562,0.00002356063,0.00005420054,0.000001606245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002276394,"about_ca_system_score_gemma":0.00005672266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001216451,"about_ca_topic_score_gemma":0.0001345654,"domain_scores_codex":[0.9994246,0.00003375828,0.0001090233,0.0002403215,0.00006354442,0.0001287443],"domain_scores_gemma":[0.999796,0.00001140933,0.0000460708,0.00008837241,0.00002977624,0.00002836503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001256635,0.00005208876,0.1864322,0.000003551802,0.00002655246,0.000002753717,0.0002908969,0.000006178306,0.8117542,0.000002847959,0.00008779884,0.001215351],"study_design_scores_gemma":[0.0004878577,0.0001212588,0.4605971,0.00000761929,0.000001829869,0.00001567354,0.00002092375,0.00001106403,0.5384806,0.00001338856,0.0001681817,0.00007444824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986718,0.00003423709,0.0001079545,0.00005851747,0.00002307226,0.0001188644,0.00000398442,0.000009550476,0.0009720137],"genre_scores_gemma":[0.9992069,0.00002437492,0.0002287176,0.00008748918,0.00001792822,0.00001347858,0.0001407715,0.000006739056,0.0002735773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2741649,"threshold_uncertainty_score":0.3413616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00769210927663474,"score_gpt":0.2103066298666708,"score_spread":0.2026145205900361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}