{"id":"W1607487366","doi":"10.1593/neo.08356","title":"Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas","year":2008,"lang":"en","type":"article","venue":"Neoplasia","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"University of California, San Francisco; Sontag Foundation","keywords":"Biology; Notch signaling pathway; Chromosome instability; HES1; Meningioma; Signal transduction; Cell biology; Cancer research; Context (archaeology); Genetics; Chromosome; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220639,0.0002357815,0.0002025438,0.0007807848,0.0001465214,0.0002539781,0.00009915528,0.0002266106,0.001421754],"category_scores_gemma":[0.0002912548,0.0001640432,0.0001423577,0.0002481639,0.0001774446,0.0001461066,0.0002692,0.0002273375,0.0002808004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002583902,"about_ca_system_score_gemma":0.0001115408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000434007,"about_ca_topic_score_gemma":0.0004539698,"domain_scores_codex":[0.9998828,0.00001497595,0.0000171983,0.00002936388,0.00003768729,0.00001797563],"domain_scores_gemma":[0.9997554,0.00002877908,0.0001231954,0.00002504064,0.00001600171,0.00005149441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002627125,0.00001424205,0.005060332,0.00002074842,0.00001309218,0.001323117,0.00002878735,0.00004366778,0.9917889,0.00006919695,0.00003976171,0.001335449],"study_design_scores_gemma":[0.00005536293,0.0005792446,0.2675176,0.00001519865,0.00007629621,0.03578304,0.0001709917,0.00126078,0.6899748,0.0006964178,0.003847606,0.00002261208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998046,0.000464418,0.0007875306,0.00003429654,0.000004804354,0.000008768512,0.0001812758,0.00003654864,0.0004363018],"genre_scores_gemma":[0.9986439,0.0003167762,0.0003623774,0.00001424556,0.000004236966,0.00000722445,0.000188575,0.000007741668,0.0004548967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421754,"threshold_uncertainty_score":0.004756212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00769210927663474,"score_gpt":0.2103066298666708,"score_spread":0.2026145205900361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}