{"id":"W1607918374","doi":"10.1002/jbmr.2043","title":"RANKL Inhibition With Denosumab Does Not Influence 3-Year Progression of Aortic Calcification or Incidence of Adverse Cardiovascular Events in Postmenopausal Women With Osteoporosis and High Cardiovascular Risk","year":2013,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Biogen; Amgen; Pfizer; Novo Nordisk; Synarc; Eli Lilly and Company","keywords":"Denosumab; Medicine; Osteoporosis; Placebo; Internal medicine; Adverse effect; Endocrinology; RANKL; Osteoprotegerin; Incidence (geometry); Bone mineral; Raloxifene; Pathology; Activator (genetics); Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351773,0.000184643,0.001014096,0.0002024456,0.0001441114,0.0003237768,0.0001904947,0.0003046984,0.0009858796],"category_scores_gemma":[0.001622454,0.0001909764,0.0008303616,0.0002541208,0.0002280131,0.0001820791,0.0001646459,0.0004965535,0.0001404158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784415,"about_ca_system_score_gemma":0.0003881575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001725147,"about_ca_topic_score_gemma":0.002907147,"domain_scores_codex":[0.9994703,0.0002050115,0.00006156652,0.00006384578,0.0001264183,0.00007280972],"domain_scores_gemma":[0.9994621,0.0001551369,0.0001477641,0.00006755826,0.00003868335,0.0001287418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5950277,0.005876169,0.1576346,0.0008036145,0.00428385,0.0002403718,0.0003220074,0.001336964,0.05067728,0.0001859867,0.001453828,0.1821576],"study_design_scores_gemma":[0.05692837,0.2095064,0.7102143,0.0001222671,0.003944679,0.0006578121,0.0001741983,0.002351109,0.009058414,0.000437954,0.006548702,0.00005585923],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940993,0.004859998,0.0000847783,0.00006688236,0.00003126437,0.00003051524,0.0002253509,0.000009832744,0.0005921576],"genre_scores_gemma":[0.9987115,0.0005840404,0.00008165871,0.00005370299,0.00001972524,0.00001884554,0.0001996011,0.000001531377,0.0003293688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001725147,"threshold_uncertainty_score":0.007148921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009678019970081645,"score_gpt":0.2699595050527317,"score_spread":0.26028148508265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}