{"id":"W1608054934","doi":"10.3233/jad-2010-1331","title":"Simple In Vitro Assays to Identify Amyloid-β Aggregation Blockers for Alzheimer's Disease Therapy","year":2010,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer","keywords":"Amyloid (mycology); In vitro; Disease; Alzheimer's disease; Neuroscience; Chemistry; Pharmacology; Medicine; Biology; Biochemistry; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006568794,0.0004359872,0.0006742824,0.0007473741,0.0001801923,0.000127625,0.0003466721,0.0001181168,0.0002710603],"category_scores_gemma":[0.0005025882,0.0003570504,0.0007602751,0.0005094638,0.0001395982,0.0005267033,0.000071659,0.00054359,0.00008037329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008408374,"about_ca_system_score_gemma":0.001424847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004090928,"about_ca_topic_score_gemma":0.000009375494,"domain_scores_codex":[0.9964845,0.000130543,0.0009256687,0.0004930167,0.001182493,0.0007837641],"domain_scores_gemma":[0.994064,0.0001959669,0.0004202335,0.0006598487,0.0007538159,0.003906091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1508779,0.01941682,0.4789692,0.0002512531,0.06582205,0.009947686,0.0007692235,0.0002639873,0.0374498,0.0003136845,0.04919042,0.186728],"study_design_scores_gemma":[0.01747435,0.001067286,0.935623,0.0002443337,0.01011225,0.00006330743,0.0001456993,0.0009458193,0.02339508,0.002740143,0.007430153,0.0007586073],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598573,0.03144466,0.00006841973,0.005248267,0.0005480682,0.002373039,0.0003511174,0.00004681408,0.00006228778],"genre_scores_gemma":[0.9960973,0.0002971014,0.00136512,0.001031531,0.0007521266,0.0001917472,0.0001591106,0.00009543686,0.00001050182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4566538,"threshold_uncertainty_score":0.9998881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03887414377691199,"score_gpt":0.3675945784351403,"score_spread":0.3287204346582283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}