{"id":"W1608126882","doi":"10.4049/jimmunol.1402641","title":"Sca-1+Lin−CD117− Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IRF8-Controlled Regulatory Dendritic Cells through Notch–RBP-J Signaling","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Chinese Academy of Medical Sciences; Chinese Academy of Sciences; Academy of Medical Sciences","keywords":"Mesenchymal stem cell; Stem cell; Cell biology; Stromal cell; Haematopoiesis; Biology; Bone marrow; Immune system; IL-2 receptor; Immunology; FOXP3; Follicular dendritic cells; Population; Regulatory T cell; Cancer research; T cell; Antigen-presenting cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005365513,0.000302677,0.0011103,0.0002286975,0.0002073922,0.00003461753,0.0008160635,0.0003017683,0.000151632],"category_scores_gemma":[0.0004611242,0.0001646909,0.0003436764,0.0003769069,0.0006353695,0.0002319288,0.0001961992,0.001301074,0.00003661594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579347,"about_ca_system_score_gemma":0.001023933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001179733,"about_ca_topic_score_gemma":0.00001150441,"domain_scores_codex":[0.9951786,0.001229242,0.001515157,0.0002187031,0.001246175,0.0006120701],"domain_scores_gemma":[0.9953996,0.001178146,0.00113668,0.0007549754,0.001355668,0.0001749667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003127934,0.000311925,0.00008223595,0.00003695817,0.0006239864,0.00005256562,0.002252389,0.001172224,0.9903782,0.0003396691,0.001098645,0.0005232741],"study_design_scores_gemma":[0.01534195,0.002551551,0.0005898992,0.0002267073,0.0006203656,0.001706249,0.004296403,0.001841159,0.9717682,0.0001504012,0.0007109376,0.0001961545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858503,0.007060489,0.002069583,0.001876953,0.001348666,0.0007901381,0.000005134196,0.00001288136,0.0009858074],"genre_scores_gemma":[0.9961123,0.0003107773,0.001066483,0.0002292234,0.0009178121,0.00000893267,0.000002344514,0.0000445386,0.001307608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01860997,"threshold_uncertainty_score":0.67159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1067258756575702,"score_gpt":0.3167778710195642,"score_spread":0.210051995361994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}