{"id":"W1608216976","doi":"10.4049/jimmunol.173.1.566","title":"Phosphatidylserine Receptor-Mediated Recognition of Archaeosome Adjuvant Promotes Endocytosis and MHC Class I Cross-Presentation of the Entrapped Antigen by Phagosome-to-Cytosol Transport and Classical Processing","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Research Council Canada","keywords":"Biology; Cell biology; Antigen presentation; MHC class I; Endosome; MHC class II; Cross-presentation; Endocytosis; Antigen processing; CD8; Cytotoxic T cell; Major histocompatibility complex; Antigen-presenting cell; Antigen; Receptor; In vitro; Biochemistry; Immunology; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006216511,0.0002151639,0.0005586992,0.0001578608,0.0002186688,0.000009120608,0.0003670559,0.0002195105,0.0000666662],"category_scores_gemma":[0.0002090263,0.000131493,0.0001131627,0.0002666732,0.001466028,0.000222906,0.00007686282,0.0004811253,0.000004367945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003575464,"about_ca_system_score_gemma":0.0001760545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008873187,"about_ca_topic_score_gemma":0.000007659126,"domain_scores_codex":[0.9980255,0.0005116879,0.0008980134,0.000155412,0.00009751249,0.0003119205],"domain_scores_gemma":[0.9982872,0.0003442038,0.0008673497,0.0002110069,0.0002668508,0.00002338098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005399858,0.0002256888,0.003988624,0.00004694619,0.0004210449,0.000001439415,0.004403768,0.000007162645,0.9661501,0.00001539043,0.00002017236,0.01931979],"study_design_scores_gemma":[0.00442949,0.001437127,0.07987806,0.0002698649,0.00008918843,0.0004427231,0.0007935503,0.000001684233,0.9112766,0.0002361565,0.0010156,0.0001299447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616823,0.03572167,0.0002355446,0.001602503,0.0002824239,0.0003891694,0.00006556501,0.00001075131,0.00001006599],"genre_scores_gemma":[0.9907177,0.008966736,0.0000916637,0.00008785616,0.00001618962,0.000007377152,0.00002628807,0.00002098048,0.00006521553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07588944,"threshold_uncertainty_score":0.540164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076328931860989,"score_gpt":0.2469839993133066,"score_spread":0.2362207099946967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}