{"id":"W1608216976","doi":"10.4049/jimmunol.173.1.566","title":"Phosphatidylserine Receptor-Mediated Recognition of Archaeosome Adjuvant Promotes Endocytosis and MHC Class I Cross-Presentation of the Entrapped Antigen by Phagosome-to-Cytosol Transport and Classical Processing","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Research Council Canada","keywords":"Biology; Cell biology; Antigen presentation; MHC class I; Endosome; MHC class II; Cross-presentation; Endocytosis; Antigen processing; CD8; Cytotoxic T cell; Major histocompatibility complex; Antigen-presenting cell; Antigen; Receptor; In vitro; Biochemistry; Immunology; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103492,0.000278181,0.0001099386,0.00008026331,0.00007065429,0.0001977746,0.00009933737,0.0002179381,0.0009854358],"category_scores_gemma":[0.00007503453,0.0001240801,0.000187008,0.00004940634,0.0001421171,0.0001745525,0.0002303817,0.0003452614,0.000368564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711146,"about_ca_system_score_gemma":0.0001456577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001734426,"about_ca_topic_score_gemma":0.0003330497,"domain_scores_codex":[0.9999217,0.00001412695,0.000006219762,0.00001354545,0.00001433739,0.00003019284],"domain_scores_gemma":[0.9999468,0.000009615893,0.00001487791,0.000005830415,0.000005035137,0.0000178701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123051,0.000009168421,0.0002223711,0.00001815972,0.000001239939,0.00002913985,0.00000759391,0.00002102769,0.99923,0.00003827304,0.000005981563,0.0002939666],"study_design_scores_gemma":[0.00001880815,0.0003302436,0.006801344,0.000006560942,0.000009799569,0.0002845773,0.00003231902,0.0005681508,0.9912018,0.00003781587,0.0007055168,0.00000300115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985986,0.0003884514,0.0005366076,0.00002019073,0.000005918991,0.000007559193,0.00004474748,0.000009400833,0.000388478],"genre_scores_gemma":[0.9981092,0.0002857353,0.0005531337,0.00001772124,0.00000456557,0.00001099065,0.0001109436,0.000004586461,0.0009032527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009854358,"threshold_uncertainty_score":0.003296614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076328931860989,"score_gpt":0.2469839993133066,"score_spread":0.2362207099946967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}