{"id":"W1608434453","doi":"10.1038/35046500","title":"Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression","year":2000,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institute on Aging","keywords":"Unfolded protein response; Endoplasmic reticulum; Presenilin; Biology; Cell biology; Downregulation and upregulation; Transmembrane protein; Missense mutation; CHOP; Genetics; Mutation; Gene; Alzheimer's disease; Disease; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632287,0.0003595897,0.0003657356,0.0006108673,0.0002987079,0.0007526288,0.0001886891,0.0002928514,0.001415759],"category_scores_gemma":[0.000275481,0.0002700424,0.0002989732,0.0002402557,0.000330058,0.0004498342,0.0004926074,0.0009088659,0.0007257364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006136455,"about_ca_system_score_gemma":0.000261861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005627161,"about_ca_topic_score_gemma":0.001109552,"domain_scores_codex":[0.9997219,0.00002899069,0.00002481669,0.00004934871,0.00007112478,0.0001037981],"domain_scores_gemma":[0.999535,0.00006291795,0.00008783223,0.00006859261,0.000101876,0.0001438109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002648029,0.00001039854,0.0001219425,0.00002001516,0.000002928954,0.00006663529,0.000008640423,0.000009426823,0.9986883,0.00008154771,0.00005715529,0.0006681694],"study_design_scores_gemma":[0.00001806159,0.00009126683,0.0157251,0.000005377607,0.00001146852,0.0004503184,0.00004250528,0.0003090525,0.9814624,0.0001330791,0.001745559,0.000005904012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890232,0.002430539,0.003585711,0.0002818053,0.00007429499,0.00004005018,0.001263246,0.0003046545,0.002996602],"genre_scores_gemma":[0.9873775,0.0008469445,0.00237773,0.000136432,0.00002611575,0.00005759826,0.001987451,0.00009267081,0.007097644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001415759,"threshold_uncertainty_score":0.004736185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002450672558223702,"score_gpt":0.2279141355088691,"score_spread":0.2254634629506454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}