{"id":"W1608661399","doi":"10.1007/bf03401824","title":"Intranasal Immunization of Mice with CpG DNA Induces Strong Systemic and Mucosal Responses That Are Influenced by Other Mucosal Adjuvants and Antigen Distribution","year":2000,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Medical Research Council","keywords":"Nasal administration; Immunology; Immunization; CpG site; CpG Oligodeoxynucleotide; Antigen; Molecular medicine; TLR9; Medicine; Biology; DNA methylation; Gene; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002568428,0.000782763,0.0002803082,0.0003249283,0.00008603428,0.0001913111,0.0001214626,0.0003408738,0.001300947],"category_scores_gemma":[0.0001306825,0.0001500054,0.0001920555,0.0001002543,0.0003482601,0.0001760142,0.0001630411,0.0008206528,0.0003358888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002080649,"about_ca_system_score_gemma":0.000250223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002298242,"about_ca_topic_score_gemma":0.0003922067,"domain_scores_codex":[0.9998229,0.00002941215,0.00001404888,0.00004228544,0.00004172984,0.0000496881],"domain_scores_gemma":[0.9997897,0.00002791533,0.00006923266,0.00001967141,0.00002189842,0.00007156665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001253993,0.00006137237,0.0001617232,0.00003431827,0.000002422033,0.00001338497,0.000005394902,0.00002752632,0.9988356,0.00001753083,0.00001319847,0.00070226],"study_design_scores_gemma":[0.0000430087,0.002083031,0.002211798,0.00001365592,0.00001914437,0.0001349284,0.00001265329,0.0003618177,0.994314,0.00002630291,0.0007764059,0.00000329676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941765,0.00104282,0.002794198,0.0001035538,0.00005020982,0.00007423737,0.0002399526,0.0001514155,0.001367069],"genre_scores_gemma":[0.9919183,0.0009878455,0.003740551,0.0001170292,0.00004000487,0.00009321568,0.0004207338,0.00003356065,0.002648852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300947,"threshold_uncertainty_score":0.004352152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006051663069048805,"score_gpt":0.2202095756359267,"score_spread":0.2141579125668779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}