{"id":"W1611839912","doi":"10.4049/jimmunol.0800902","title":"Spontaneous Autoimmunity Sufficiently Potent to Induce Diabetes Mellitus Is Insufficient to Protect against Insulinoma","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Nod; Autoimmunity; Insulinoma; Biology; Immune system; CD8; NOD mice; Immunology; Insulitis; Clonal deletion; Cancer research; Immune tolerance; Tumor microenvironment; Cytotoxic T cell; Transgene; Genetically modified mouse; T cell; T-cell receptor; Endocrinology; Insulin; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003639362,0.0005225552,0.0004280609,0.0002839004,0.0001231019,0.0004935765,0.0002019414,0.0003841653,0.001216667],"category_scores_gemma":[0.0003402533,0.0001853485,0.0003320726,0.0001518445,0.0001966246,0.0003207276,0.0002785098,0.001070831,0.0004561995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123084,"about_ca_system_score_gemma":0.0002096541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001093719,"about_ca_topic_score_gemma":0.0001955727,"domain_scores_codex":[0.9997491,0.00004504095,0.00003957394,0.00004280914,0.000054558,0.0000688837],"domain_scores_gemma":[0.9993383,0.0001168186,0.0001826695,0.0001108041,0.00003017522,0.0002212338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003159338,0.0001622541,0.0009814976,0.00004106527,0.00001502342,0.000176235,0.000009593109,0.00007839093,0.9965269,0.0001418537,0.0000433079,0.001508088],"study_design_scores_gemma":[0.0002157008,0.006937744,0.02493202,0.0000599204,0.0001354912,0.003676142,0.00006556926,0.002736025,0.9553392,0.0004670424,0.005412124,0.00002306747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941545,0.001171201,0.002049835,0.00009142679,0.00007252442,0.00003248232,0.0001789736,0.0001884998,0.002060426],"genre_scores_gemma":[0.9959187,0.0007238807,0.001178583,0.00009701112,0.0000386167,0.00004628608,0.0004013831,0.00003475545,0.001560844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216667,"threshold_uncertainty_score":0.004070222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127950800034343,"score_gpt":0.2274112615443018,"score_spread":0.2161317535439583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}